Vagal sensory neurons drive mucous cell metaplasia

Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory response.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of allergy and clinical immunology 2020-06, Vol.145 (6), p.1693-1696.e4
Hauptverfasser:	Talbot, Sébastien, Doyle, Benjamin, Huang, Junwei, Wang, Jo-Chiao, Ahmadi, Maryam, Roberson, David P., Yekkirala, Ajay, Foster, Simmie L., Browne, Liam E., Bean, Bruce P., Levy, Bruce D., Woolf, Clifford J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Female Immunity, Innate - physiology Inflammation - pathology Lung - pathology Male Metaplasia - pathology Metaplasia - physiopathology Mice Mice, Inbred C57BL Mucus - physiology Sensory Receptor Cells - physiology Vagus Nerve - physiology
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Beschreibung
Zusammenfassung:	Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory response.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2020.01.003