Results of Complex Immunopharmacological Analysis of the Mechanisms of Action of Bioregulation Agents

Elucidation of the pharmacodynamic mechanisms of drugs capable of potentiating the effects of non-steroidal anti-inflammatory drugs is an important task. In this in vitro study, the ability of Traumeel S to influence the innate and acquired immunity was evaluated. Traumeel S was found to reduce acti...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2021-11, Vol.172 (1), p.38-41
Hauptverfasser:	Kazimirskii, А. N., Salmasi, Z. М., Poryadin, G. V., Kukes, I. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adaptive Immunity - drug effects Analysis Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology B cells Biomedical and Life Sciences Biomedicine Cell Biology Cytokines Drug therapy Ethylenediaminetetraacetic acid Extracellular Traps - immunology fas Receptor - analysis Granulocytes HLA-DR Antigens - immunology Humans Immune system Immunity, Innate - drug effects Immunology Infections Inflammation Inflammation - drug therapy Inflammation - pathology Internal Medicine Laboratory Medicine Leukocytes (neutrophilic) Leukocytosis - immunology Lymphocyte Subsets - immunology Lymphocytes Minerals - pharmacology NAD(P)H oxidase NADPH Oxidases - metabolism Neutrophils Neutrophils - immunology Nonsteroidal anti-inflammatory drugs Oxidases Pathology Pharmacodynamics Plant Extracts - pharmacology T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:	Elucidation of the pharmacodynamic mechanisms of drugs capable of potentiating the effects of non-steroidal anti-inflammatory drugs is an important task. In this in vitro study, the ability of Traumeel S to influence the innate and acquired immunity was evaluated. Traumeel S was found to reduce activities of NADPH oxidase and neutrophil extracellular traps, as well as to evoke anti-inflammatory activity of lymphocyte subpopulations.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-021-05326-w