Population Pharmacokinetics, Exposure-Response, and Probability of Target Attainment Analyses for Tedizolid in Adolescent Patients with Acute Bacterial Skin and Skin Structure Infections

Population Pharmacokinetics, Exposure-Response, and Probability of Target Attainment Analyses for Tedizolid in Adolescent Patients with Acute Bacterial Skin and Skin Structure Infections

Tedizolid phosphate is an oxazolidinone antibacterial agent approved for the treatment of Gram-positive acute bacterial skin and skin structure infections (ABSSSIs) in patients aged ≥12 years. To support the use of tedizolid phosphate in adolescents with ABSSSIs, a population pharmacokinetic (PK) mo...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2021-11, Vol.65 (12), p.e0089521
Hauptverfasser: Li, Dan, Sabato, Philip E, Guiastrennec, Benjamin, Ouerdani, Aziz, Feng, Hwa-Ping, Duval, Vincent, De Anda, Carisa S, Sears, Pamela S, Chou, Margaret Z, Hardalo, Catherine, Broyde, Natalya, Rizk, Matthew L
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Anti-Bacterial Agents - therapeutic use
Antimicrobial Chemotherapy
Child
Clinical Therapeutics
Humans
Oxazolidinones
Probability
Skin Diseases, Bacterial - drug therapy
Tetrazoles
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Zusammenfassung:Tedizolid phosphate is an oxazolidinone antibacterial agent approved for the treatment of Gram-positive acute bacterial skin and skin structure infections (ABSSSIs) in patients aged ≥12 years. To support the use of tedizolid phosphate in adolescents with ABSSSIs, a population pharmacokinetic (PK) model, developed using adult and pediatric data, was updated to include PK data from a phase 3 clinical trial (PN012) that evaluated the safety and efficacy of once-daily oral or intravenous 200-mg tedizolid phosphate treatment in adolescents (12 to
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00895-21