Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants

To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with...

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Veröffentlicht in:The American journal of tropical medicine and hygiene 2021-11, Vol.105 (5), p.1227-1229
Hauptverfasser: Neuman, Benjamin W, Brashear, Wesley A, Brun, Marcel, Chaki, Sankar P, Fischer, Rebecca S B, Guidry, Sierra J, Hill, Joshua E, Hillhouse, Andrew E, Johnson, Charles D, Kahl-McDonagh, Melissa M, Metz, Richard P, Rice-Ficht, Allison C, Shuford, Jennifer A, Skaggs, Tiffany A, Stull, Matthew A, Threadgill, David W, Akpalu, Yao, Zuelke, Kurt
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Sprache:eng
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Zusammenfassung:To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.21-0542