Effects of tofogliflozin on adrenocorticotropic hormone, renin and aldosterone, and cortisol levels in elderly patients with diabetes mellitus: A retrospective study of a patient cohort

Adrenocorticotropic hormone (ACTH) and cortisol reportedly play a role in glycemic control in patients with type 2 diabetes mellitus (T2DM); however, the underlying mechanism remains controversial. We retrospectively investigated the effect of tofogliflozin on serum ACTH and cortisol levels in elder...

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Veröffentlicht in:	Medicine (Baltimore) 2021-11, Vol.100 (45), p.e27638-e27638
Hauptverfasser:	Higashikawa, Toshihiro, Ito, Tomohiko, Mizuno, Takurou, Ishigami, Keiichirou, Kuroki, Kengo, Maekawa, Naoto, Usuda, Daisuke, Morita, Takuro, Hamada, Kazu, Takagi, Susumu, Takeshima, Kento, Yamada, Shinya, Sangen, Ryusho, Izumida, Toshihide, Mori, Hideyuki, Kiyosawa, Jun, Saito, Atsushi, Iguchi, Masaharu, Nakahashi, Takeshi, Kasamaki, Yuji, Fukuda, Akihiro, Kanda, Tsugiyasu, Okuro, Masashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone Aged Aldosterone Benzhydryl Compounds Diabetes Mellitus, Type 2 - drug therapy Glucosides Humans Hydrocortisone Observational Study Renin Retrospective Studies
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Zusammenfassung:	Adrenocorticotropic hormone (ACTH) and cortisol reportedly play a role in glycemic control in patients with type 2 diabetes mellitus (T2DM); however, the underlying mechanism remains controversial. We retrospectively investigated the effect of tofogliflozin on serum ACTH and cortisol levels in elderly patients with T2DM.Patients received 20 mg tofogliflozin daily for 3 months. Serum ACTH and cortisol levels were measured at baseline, as well as after 1 month and 3 months of tofogliflozin therapy.Serum ACTH levels were significantly reduced 3 months after tofogliflozin treatment (P
ISSN:	0025-7974 1536-5964
DOI:	10.1097/MD.0000000000027638