How Does Obesity Cause Cancer?

In one of the largest epidemiological studies in the United Kingdom, excess body mass was clearly associated with more than a dozen types of cancer, including a 41% increased risk of uterine cancer and a 10% or more risk of developing gallbladder, kidney, liver, and colon cancers, whereas being underweight decreased the risk of prostate and post-menopausal breast cancers [1]. [...]Kolb and Zhang review the potential role of inflammation in linking obesity to estrogen-positive breast cancer in post-menopausal women [11]. [...]Wright and colleagues review the potential links between body mass, diet, and host metabolism to how well patients respond to anti-cancer treatment [17]. Cortesi, L.; Sebastiani, F.; Iannone, A.; Marcheselli, L.; Venturelli, M.; Piombino, C.; Toss, A.; Federico, M. Lifestyle Intervention on Body Weight and Physical Activity in Patients with Breast Cancer can reduce the Risk of Death in Obese Women: The EMILI Study.