Rectally shed SARS-CoV-2 in COVID-19 inpatients is consistently lower than respiratory shedding and lacks infectivity

Rectally shed SARS-CoV-2 in COVID-19 inpatients is consistently lower than respiratory shedding and lacks infectivity

Assessment of whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been propagated during intestinal passage and infectivity is conserved when shed rectally by hospitalized individuals. An exploratory cohort study including 28 inpatients with coronavirus disease 2019 with estimat...

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Veröffentlicht in:Clinical microbiology and infection 2022-02, Vol.28 (2), p.304.e1-304.e3
Hauptverfasser: Pedersen, Rune Micha, Tornby, Ditte Sandfeld, Bang, Line Lundegård, Madsen, Lone Wulff, Skov, Marianne Nielsine, Sydenham, Thomas Vognbjerg, Steinke, Kat, Jensen, Thøger Gorm, Johansen, Isik Somuncu, Andersen, Thomas Emil
Format: Artikel
Sprache:eng
Schlagworte:
Cohort Studies
Coronavirus disease 2019
COVID-19
Faeces
Gastrointestinal infection
Humans
Inpatients
Pharynx
Research Note
RNA, Viral - genetics
SARS-CoV-2
Severe acute respiratory syndrome Coronavirus 2
Shedding
Transmission
Virus
Virus Shedding
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Zusammenfassung:Assessment of whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been propagated during intestinal passage and infectivity is conserved when shed rectally by hospitalized individuals. An exploratory cohort study including 28 inpatients with coronavirus disease 2019 with estimation of RNA levels by RT-PCR and of viral infectivity by culturing of viral material sampled concomitantly and identically from pharynx and rectum. SARS-CoV-2 RNA was detected more frequently (91%, 30/33 versus 42%, 14/33, p
ISSN:1198-743X
1469-0691
DOI:10.1016/j.cmi.2021.10.023