Blood-thirsty: S1PR5 and TRM

In this elegant study, Evrard et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210116) find that sphingosine 1-phosphate receptor 5 (S1PR5) powerfully impairs tissue-resident memory T cell (TRM) formation, and that tissue-derived TGF-β limits S1pr5 expression by infiltrating T cells.

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 2022-01, Vol.219 (1)
Hauptverfasser:	Hallisey, Victoria M, Schwab, Susan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Insights Memory T Cells Sphingosine-1-Phosphate Receptors
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	In this elegant study, Evrard et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210116) find that sphingosine 1-phosphate receptor 5 (S1PR5) powerfully impairs tissue-resident memory T cell (TRM) formation, and that tissue-derived TGF-β limits S1pr5 expression by infiltrating T cells.
ISSN:	0022-1007 1540-9538
DOI:	10.1084/jem.20211971