Cre/CysC ratio may predict muscle composition and is associated with glucose disposal ability and macrovascular disease in patients with type 2 diabetes

IntroductionSince the ratio of creatinine to cystatin C (Cre/CysC) can reflect muscle volume, it has been proven to be a predictor of sarcopenia in patients with or without diabetes. Here, we investigated the predictive value of Cre/CysC for the skeletal muscle composition and its correlations with...

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Veröffentlicht in:	BMJ open diabetes research & care 2021-11, Vol.9 (2), p.e002430, Article 002430
Hauptverfasser:	Yang, Qing, Zhang, Mei, Sun, Peng, Li, Yanying, Xu, Huichao, Wang, Kejun, Shen, Hongshan, Ban, Bo, Liu, Fupeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Body fat Body mass index Clinical care/Education/Nutrition Creatinine Cross-Sectional Studies Diabetes diabetes complications Diabetes Mellitus, Type 2 - complications Disease Endocrinology & Metabolism Glucose Hospitals Humans Insulin Integrases Laboratories Life Sciences & Biomedicine Medical imaging muscle weakness Muscle, Skeletal - diagnostic imaging Musculoskeletal system nutritional sciences Patients Sarcopenia Science & Technology Software Statistical analysis type 2 diabetes
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Zusammenfassung:	IntroductionSince the ratio of creatinine to cystatin C (Cre/CysC) can reflect muscle volume, it has been proven to be a predictor of sarcopenia in patients with or without diabetes. Here, we investigated the predictive value of Cre/CysC for the skeletal muscle composition and its correlations with glucose disposal ability and diabetic complications in patients with type 2 diabetes.Research design and methodsThe skeletal muscle index (SMI) and mean skeletal muscle attenuation (MMA) values of 193 patients with type 2 diabetes were obtained through analyses of CT images at the lumbar 3 level.ResultsSerum Cre/CysC was significantly correlated with both the SMI (r=0.375, p
ISSN:	2052-4897 2052-4897
DOI:	10.1136/bmjdrc-2021-002430