Association of Smoking, Alcohol Consumption, Blood Pressure, Body Mass Index, and Glycemic Risk Factors With Age-Related Macular Degeneration: A Mendelian Randomization Study

IMPORTANCE: Advanced age-related macular degeneration (AMD) is a leading cause of blindness in Western countries. Causal, modifiable risk factors need to be identified to develop preventive measures for advanced AMD. OBJECTIVE: To assess whether smoking, alcohol consumption, blood pressure, body mas...

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Veröffentlicht in:	Archives of ophthalmology (1960) 2021-12, Vol.139 (12), p.1299-1306
Hauptverfasser:	Kuan, Valerie, Warwick, Alasdair, Hingorani, Aroon, Tufail, Adnan, Cipriani, Valentina, Burgess, Stephen, Sofat, Reecha
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alcohol Alcohol Drinking - adverse effects Alcohol Drinking - epidemiology Alcohol use Alcoholic beverages Angiogenesis Inhibitors Atrophy Blindness Blood pressure Blood Pressure - genetics Body Mass Index Cigarette smoking Comments Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Drug addiction Fasting Genome-Wide Association Study Genomes Hemoglobin Humans Insulin Macular degeneration Mendelian Randomization Analysis Online First Original Investigation Public health Risk Factors Smoking - adverse effects Smoking cessation Vascular Endothelial Growth Factor A Visual Acuity Wet Macular Degeneration
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Zusammenfassung:	IMPORTANCE: Advanced age-related macular degeneration (AMD) is a leading cause of blindness in Western countries. Causal, modifiable risk factors need to be identified to develop preventive measures for advanced AMD. OBJECTIVE: To assess whether smoking, alcohol consumption, blood pressure, body mass index, and glycemic traits are associated with increased risk of advanced AMD. DESIGN, SETTING, PARTICIPANTS: This study used 2-sample mendelian randomization. Genetic instruments composed of variants associated with risk factors at genome-wide significance (P
ISSN:	2168-6165 2168-6173
DOI:	10.1001/jamaophthalmol.2021.4601