AMPK CA(R)Sts a new light on amino acid sensing

AMPK CA(R)Sts a new light on amino acid sensing

AMP‐activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and ADP/ATP ratios, or glucose‐ and fatty acid‐derived metabolites. However, its ability to sense alterations in amino acid levels is poorly understood. Recent work by Yuan et ...

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Veröffentlicht in:The EMBO journal 2021-11, Vol.40 (21), p.e109575-n/a
1. Verfasser: Brown, Kristin K
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine diphosphate
Amino Acids
AMP-Activated Protein Kinases - genetics
AMP-Activated Protein Kinases - metabolism
Chemoreception
EMBO03
EMBO21
Energy Metabolism
Fatty Acids
Glucose
Kinases
Metabolites
News & Views
Protein kinase
Sulfur
Views
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Beschreibung
Zusammenfassung:AMP‐activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and ADP/ATP ratios, or glucose‐ and fatty acid‐derived metabolites. However, its ability to sense alterations in amino acid levels is poorly understood. Recent work by Yuan et al (2021) identifies a novel mechanism of AMPK regulation responsive to changes in availability of the sulfur‐containing amino acid cysteine. Graphical Abstract Recent work uncovers a role for AMP‐activated protein kinase AMPK in countering low amino acid levels to support cell survival.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.2021109575