Vaccine-induced thrombotic thrombocytopenia following coronavirus vaccine: A narrative review

The novel coronavirus pandemic has taken a toll on the global healthcare systems and economy. Safety precautions, along with vaccination, are the most effective preventive measures. The global vaccination program against COVID-19 has dramatically reduced the number of deaths and cases. However, the incidence of thrombotic events and thrombocytopenia post-COVID-19 vaccination known as vaccine-induced thrombotic thrombocytopenia has raised safety concerns. This has led to an element of vaccine hesitancy. The exact mechanism for vaccine-induced thrombotic thrombocytopenia is unknown. Although the incidence of thrombosis associated with COVID-19 vaccination is low, it still requires attention, especially in older people, smokers, and people with preexisting comorbidities. This study aims to review the pathophysiology, diagnosis, and management of vaccine-induced thrombotic thrombocytopenia, to provide a concise and comprehensive update. •The global vaccination program against COVID-19 has greatly reduced the number of deaths and cases.•This review highlights the potential pathophysiology, clinical diagnosis, and management of COVID vaccine associated VITT.•The escalating incidence of such cases has raised concerns regarding the safety profile of available vaccines.•Despite several cases of VITT being reported, the benefits of vaccines continue to markedly outweigh the rare ramifications.