ApoE and immunity in Alzheimer’s disease and related tauopathies: Low-density lipoprotein receptor to the rescue

ApoE and immunity in Alzheimer’s disease and related tauopathies: Low-density lipoprotein receptor to the rescue

In this issue of Neuron, Shi et al. (2021) show a protective role for the low-density lipoprotein receptor (LDLR) in tau pathology. Brain overexpression of LDLR lowers apolipoprotein E (apoE), suppresses microglial activation, preserves myelin, and ameliorates neurodegeneration, pointing the way tow...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2021-08, Vol.109 (15), p.2363-2365, Article 2363
Hauptverfasser: Mendiola, Andrew S, Tognatta, Reshmi, Yan, Zhaoqi, Akassoglou, Katerina
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer Disease - genetics
Alzheimer's disease
Apolipoprotein E
Apolipoproteins E - genetics
Brain
Brain - metabolism
Dementia
Gene expression
Humans
Immunity (Disease)
Lipoproteins, LDL
Low density lipoprotein receptors
Microscopy
Myelin
Neurodegeneration
Neurodegenerative diseases
Neurons
Pathogenesis
Pathology
Permeability
Receptor density
Receptors, LDL - genetics
Receptors, LDL - metabolism
Tau protein
Tauopathies - genetics
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Zusammenfassung:In this issue of Neuron, Shi et al. (2021) show a protective role for the low-density lipoprotein receptor (LDLR) in tau pathology. Brain overexpression of LDLR lowers apolipoprotein E (apoE), suppresses microglial activation, preserves myelin, and ameliorates neurodegeneration, pointing the way toward potential new therapies.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2021.07.013