Non-invasive measurement of pulse pressure variation using a finger-cuff method in obese patients having laparoscopic bariatric surgery

Pulse pressure variation (PPV) is a dynamic cardiac preload variable used to predict fluid responsiveness. PPV can be measured non-invasively using innovative finger-cuff systems allowing for continuous arterial pressure waveform recording, e.g., the Nexfin system [BMEYE B.V., Amsterdam, The Netherlands; now Clearsight (Edwards Lifesciences, Irvine, CA, USA)] (PPV Finger ). However, the agreement between PPV Finger and PPV derived from an arterial catheter (PPV ART ) in obese patients having laparoscopic bariatric surgery is unknown. We compared PPV Finger and PPV ART at 6 time points in 60 obese patients having laparoscopic bariatric surgery in a secondary analysis of a prospective method comparison study. We used Bland–Altman analysis to assess absolute agreement between PPV Finger and PPV ART . The predictive agreement for fluid responsiveness between PPV Finger and PPV ART was evaluated across three PPV categories (PPV 13%) as concordance rate of paired measurements and Cohen’s kappa. The overall mean of the differences between PPV Finger and PPV ART was 0.5 ± 4.6% (95%-LoA − 8.6 to 9.6%) and the overall predictive agreement was 72.4% with a Cohen’s kappa of 0.53. The mean of the differences was − 0.7 ± 3.8% (95%-LoA − 8.1 to 6.7%) without pneumoperitoneum in horizontal position and 1.1 ± 4.8% (95%-LoA − 8.4 to 10.5%) during pneumoperitoneum in reverse-Trendelenburg position. The absolute agreement and predictive agreement between PPV Finger and PPV ART are moderate in obese patients having laparoscopic bariatric surgery.