The Effect of Epinephrine Dosing Intervals on Outcomes from Pediatric In-Hospital Cardiac Arrest
Kienzle et al discuss their study on the association between epinephrine dosing intervals and pediatric cardiac arrest outcomes. Single-center retrospective cohort study of children (1 minute of cardiopulmonary resuscitation and>2 doses of epinephrine for an index in-hospital cardiac arrest. Expo...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2021-10, Vol.204 (8), p.977-985 |
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| container_title | American journal of respiratory and critical care medicine |
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| creator | Kienzle, Martha F. Morgan, Ryan W. Faerber, Jennifer A. Graham, Kathryn Katcoff, Hannah Landis, William P. Topjian, Alexis A. Kilbaugh, Todd J. Nadkarni, Vinay M. Berg, Robert A. Sutton, Robert M. |
| description | Kienzle et al discuss their study on the association between epinephrine dosing intervals and pediatric cardiac arrest outcomes. Single-center retrospective cohort study of children (1 minute of cardiopulmonary resuscitation and>2 doses of epinephrine for an index in-hospital cardiac arrest. Exposure was epinephrine dosing interval 2 minutes. The primary outcome was survival to hospital discharge with a favorable neurobehavioral outcome (Pediatric Cerebral Performance Category score 1-2 or unchanged). Logistic regression evaluated the association between dosing interval and outcomes; additional analyses explored duration of cardiopulmonary resuscitation (CPR) as a mediator. In a subgroup, the effect of dosing interval on diastolic blood pressure was investigated. |
| doi_str_mv | 10.1164/rccm.202012-4437OC |
| format | Article |
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Single-center retrospective cohort study of children (<18 years of age) who received >1 minute of cardiopulmonary resuscitation and>2 doses of epinephrine for an index in-hospital cardiac arrest. Exposure was epinephrine dosing interval <2 minutes (frequent epinephrine) versus >2 minutes. The primary outcome was survival to hospital discharge with a favorable neurobehavioral outcome (Pediatric Cerebral Performance Category score 1-2 or unchanged). Logistic regression evaluated the association between dosing interval and outcomes; additional analyses explored duration of cardiopulmonary resuscitation (CPR) as a mediator. In a subgroup, the effect of dosing interval on diastolic blood pressure was investigated.</description><subject>Cardiac arrest</subject><subject>Cardiopulmonary resuscitation</subject><subject>Clinical outcomes</subject><subject>CPR</subject><subject>Drug dosages</subject><subject>Heart attacks</subject><subject>Hormones</subject><subject>Original</subject><subject>Pediatrics</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkU1LxDAQhoMorl9_wFPAi5dqPtv0IizrqgsL62EFbzFNUjfSNjVpBf-9WXYR9DIzzDzzMsMLwCVGNxjn7DZo3d4QRBAmGWO0WM0OwAnmlGesLNBhqlFB06R8nYDTGD9QAgVGx2BCGck5oegEvK03Fs7r2uoB-hrOe9fZfhNShPc-uu4dLrrBhi_VROg7uBoH7VsbYR18C5-tcWoITicoe_Kxd4Nq4EyF1NZwGoKNwzk4qtOyvdjnM_DyMF_PnrLl6nExmy4zzVAxZDZH2FQsL4nl1rCaE6ORorwqqOFM1GXFhC50ZZDg3GAsGKe4YFUimK4qQ8_A3U63H6vWGm27IahG9sG1KnxLr5z8O-ncRr77Lyk4ZTkWSeB6LxD855gul62L2jaN6qwfoySck7LMC0ESevUP_fBj6NJ7iRI555iRrSDZUTr4GIOtf4_BSG4NlFsD5c5AuTOQ_gA-546W</recordid><startdate>20211015</startdate><enddate>20211015</enddate><creator>Kienzle, Martha F.</creator><creator>Morgan, Ryan W.</creator><creator>Faerber, Jennifer A.</creator><creator>Graham, Kathryn</creator><creator>Katcoff, Hannah</creator><creator>Landis, William P.</creator><creator>Topjian, Alexis A.</creator><creator>Kilbaugh, Todd J.</creator><creator>Nadkarni, Vinay M.</creator><creator>Berg, Robert A.</creator><creator>Sutton, Robert M.</creator><general>American Thoracic Society</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211015</creationdate><title>The Effect of Epinephrine Dosing Intervals on Outcomes from Pediatric In-Hospital Cardiac Arrest</title><author>Kienzle, Martha F. ; Morgan, Ryan W. ; Faerber, Jennifer A. ; Graham, Kathryn ; Katcoff, Hannah ; Landis, William P. ; Topjian, Alexis A. ; Kilbaugh, Todd J. ; Nadkarni, Vinay M. ; Berg, Robert A. ; Sutton, Robert M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-e601db4692e5ed4f52dc0a35b73d548f9b48c7cbd0855d118453174b35b4cbbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cardiac arrest</topic><topic>Cardiopulmonary resuscitation</topic><topic>Clinical outcomes</topic><topic>CPR</topic><topic>Drug dosages</topic><topic>Heart attacks</topic><topic>Hormones</topic><topic>Original</topic><topic>Pediatrics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kienzle, Martha F.</creatorcontrib><creatorcontrib>Morgan, Ryan W.</creatorcontrib><creatorcontrib>Faerber, Jennifer A.</creatorcontrib><creatorcontrib>Graham, Kathryn</creatorcontrib><creatorcontrib>Katcoff, Hannah</creatorcontrib><creatorcontrib>Landis, William P.</creatorcontrib><creatorcontrib>Topjian, Alexis A.</creatorcontrib><creatorcontrib>Kilbaugh, Todd J.</creatorcontrib><creatorcontrib>Nadkarni, Vinay M.</creatorcontrib><creatorcontrib>Berg, Robert A.</creatorcontrib><creatorcontrib>Sutton, Robert M.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of respiratory and critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kienzle, Martha F.</au><au>Morgan, Ryan W.</au><au>Faerber, Jennifer A.</au><au>Graham, Kathryn</au><au>Katcoff, Hannah</au><au>Landis, William P.</au><au>Topjian, Alexis A.</au><au>Kilbaugh, Todd J.</au><au>Nadkarni, Vinay M.</au><au>Berg, Robert A.</au><au>Sutton, Robert M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Epinephrine Dosing Intervals on Outcomes from Pediatric In-Hospital Cardiac Arrest</atitle><jtitle>American journal of respiratory and critical care medicine</jtitle><date>2021-10-15</date><risdate>2021</risdate><volume>204</volume><issue>8</issue><spage>977</spage><epage>985</epage><pages>977-985</pages><issn>1073-449X</issn><eissn>1535-4970</eissn><abstract>Kienzle et al discuss their study on the association between epinephrine dosing intervals and pediatric cardiac arrest outcomes. 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| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2021-10, Vol.204 (8), p.977-985 |
| issn | 1073-449X 1535-4970 |
| language | eng |
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| source | American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Cardiac arrest Cardiopulmonary resuscitation Clinical outcomes CPR Drug dosages Heart attacks Hormones Original Pediatrics |
| title | The Effect of Epinephrine Dosing Intervals on Outcomes from Pediatric In-Hospital Cardiac Arrest |
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