The Effect of Epinephrine Dosing Intervals on Outcomes from Pediatric In-Hospital Cardiac Arrest

Kienzle et al discuss their study on the association between epinephrine dosing intervals and pediatric cardiac arrest outcomes. Single-center retrospective cohort study of children (1 minute of cardiopulmonary resuscitation and>2 doses of epinephrine for an index in-hospital cardiac arrest. Exposure was epinephrine dosing interval 2 minutes. The primary outcome was survival to hospital discharge with a favorable neurobehavioral outcome (Pediatric Cerebral Performance Category score 1-2 or unchanged). Logistic regression evaluated the association between dosing interval and outcomes; additional analyses explored duration of cardiopulmonary resuscitation (CPR) as a mediator. In a subgroup, the effect of dosing interval on diastolic blood pressure was investigated.