Genetic Support of A Causal Relationship Between Iron Status and Type 2 Diabetes: A Mendelian Randomization Study

Iron overload is a known risk factor for type 2 diabetes (T2D); however, iron overload and iron deficiency have both been associated with metabolic disorders in observational studies. Using mendelian randomization (MR), we assessed how genetically predicted systemic iron status affected T2D risk. A...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2021-11, Vol.106 (11), p.e4641-e4651
Hauptverfasser:	Wang, Xinhui, Fang, Xuexian, Zheng, Wanru, Zhou, Jiahui, Song, Zijun, Xu, Mingqing, Min, Junxia, Wang, Fudi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - metabolism Case-Control Studies Consortia Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Female Ferritin Follow-Up Studies Genetic Predisposition to Disease Genetics Genome-Wide Association Study Humans Iron - metabolism Iron deficiency anemia Iron Overload - complications Male Medical research Medicine, Experimental Mendelian Randomization Analysis Online Only Polymorphism, Single Nucleotide Prognosis Risk Factors Transferrin Type 2 diabetes
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Zusammenfassung:	Iron overload is a known risk factor for type 2 diabetes (T2D); however, iron overload and iron deficiency have both been associated with metabolic disorders in observational studies. Using mendelian randomization (MR), we assessed how genetically predicted systemic iron status affected T2D risk. A 2-sample MR analysis was used to obtain a causal estimate. We selected genetic variants strongly associated (P
ISSN:	0021-972X 1945-7197
DOI:	10.1210/clinem/dgab454