Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months

Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months

In a longitudinal study involving nearly 4000 health care workers in Israel who had received two doses of BNT162b2 vaccine, levels of spike-binding IgG and neutralizing antibody decreased and did so to a greater extent in men, persons 65 years of age or older, and persons with immunosuppression. Obe...

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Veröffentlicht in:The New England journal of medicine 2021-12, Vol.385 (24), p.e84-e84
Hauptverfasser: Levin, Einav G, Lustig, Yaniv, Cohen, Carmit, Fluss, Ronen, Indenbaum, Victoria, Amit, Sharon, Doolman, Ram, Asraf, Keren, Mendelson, Ella, Ziv, Arnona, Rubin, Carmit, Freedman, Laurence, Kreiss, Yitshak, Regev-Yochay, Gili
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age Factors
Age groups
Aged
Antibodies
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
BNT162 Vaccine - immunology
Body Mass Index
Cohort Studies
Computer simulation
Coronavirus
Coronaviruses
COVID-19 - immunology
COVID-19 - prevention & control
COVID-19 vaccines
Female
Health care
Health Personnel
Humans
Immune response (humoral)
Immunization, Secondary
Immunocompromised Host
Immunogenicity, Vaccine
Immunoglobulin G
Immunoglobulin G - blood
Immunosuppression
Infections
Infectious Disease
Israel
Linear Models
Male
Medical personnel
Middle Aged
Original
Questionnaires
Severe acute respiratory syndrome coronavirus 2
Sex Factors
Software
Statistical analysis
Time Factors
Vaccine Efficacy
Vaccines
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Zusammenfassung:In a longitudinal study involving nearly 4000 health care workers in Israel who had received two doses of BNT162b2 vaccine, levels of spike-binding IgG and neutralizing antibody decreased and did so to a greater extent in men, persons 65 years of age or older, and persons with immunosuppression. Obese persons had higher levels of antibody than nonobese persons.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa2114583