SARS-CoV-2 in children with cancer or after haematopoietic stem cell transplant: An analysis of 131 patients

There are limited data on SARS-CoV-2 (COVID-19) infection in children with cancer or after haematopoietic stem cell transplant (HSCT). We describe the severity and outcomes of SARS-COV-2 in these patients and identify factors associated with severe disease. This was a multinational, observational st...

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Veröffentlicht in:	European journal of cancer (1990) 2021-12, Vol.159, p.78-86
Hauptverfasser:	Haeusler, Gabrielle M., Ammann, Roland A., Carlesse, Fabianne, Groll, Andreas H., Averbuch, Dina, Castagnola, Elio, Agyeman, Philipp K.A., Phillips, Bob, Gilli, Flávio, Solopova, Galina, Attarbaschi, Andishe, Wegehaupt, Oliver, Speckmann, Carsten, Sung, Lillian, Lehrnbecher, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Factors Asymptomatic Cancer Chemotherapy Child Child, Preschool Children Coinfection Comorbidity Confidence intervals Coronaviruses Cough COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 - mortality Fatalities Female Fever Haematopoietic stem cell transplantation Health risks Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Humans Immunodeficiency Leukemia Lymphoma Male Neoplasms - diagnosis Neoplasms - epidemiology Neoplasms - mortality Neutropenia Neutropenia - epidemiology Original Research Patients Polymerase chain reaction Primary immunodeficiencies Prognosis Rhinitis Risk Assessment Risk Factors SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Signs and symptoms Solid tumors Statistical analysis Stem cell transplantation Stem cells Time Factors Viral diseases Viruses
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Zusammenfassung:	There are limited data on SARS-CoV-2 (COVID-19) infection in children with cancer or after haematopoietic stem cell transplant (HSCT). We describe the severity and outcomes of SARS-COV-2 in these patients and identify factors associated with severe disease. This was a multinational, observational study of children (aged
ISSN:	0959-8049 1879-0852
DOI:	10.1016/j.ejca.2021.09.027