Cytokine profile and cytoskeletal changes after herpes simplex virus type 1 infection in human trabecular meshwork cells

Uveitis caused by herpes simplex virus (HSV)‐1 is characterized by increased intraocular pressure (IOP) in the presence of anterior chamber inflammation. Despite their clinical significance, the pathogenic changes associated with HSV‐1 infection in trabecular meshwork (TM) cells, the key cell type r...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2021-10, Vol.25 (19), p.9295-9305
Hauptverfasser:	Choi, Jin A., Ju, Hyun‐hee, Kim, Ju‐Eun, Lee, Jiyoung, Jee, Donghyun, Park, Chan Kee, Paik, Soon‐young
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Anterior chamber Antibodies Biomarkers Cells, Cultured Connective tissue growth factor Connective tissues Cytokines Cytokines - metabolism Cytomegalovirus Cytoskeleton Cytoskeleton - metabolism Enzyme inhibitors Extracellular matrix Fibronectin glaucoma Growth factors Herpes simplex Herpes Simplex - metabolism Herpes Simplex - virology herpes virus Herpes viruses Herpesvirus 1, Human - physiology Host-Pathogen Interactions HSV_1 Humans Infections Inflammation Inflammation Mediators - metabolism intraocular pressure Kinases MCP‐1 Monocyte chemoattractant protein Monocytes Muscle contraction Original Proteins R&D Research & development rho GTP-Binding Proteins - metabolism RhoA protein Signal Transduction Smooth muscle Trabecular Meshwork - metabolism Trabecular Meshwork - pathology Trabecular Meshwork - virology Uveitis Uveitis, Anterior - metabolism Uveitis, Anterior - virology Virus Replication
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Zusammenfassung:	Uveitis caused by herpes simplex virus (HSV)‐1 is characterized by increased intraocular pressure (IOP) in the presence of anterior chamber inflammation. Despite their clinical significance, the pathogenic changes associated with HSV‐1 infection in trabecular meshwork (TM) cells, the key cell type regulating IOP, have not been completely elucidated. In this study, cytokine array analyses showed a significant stepwise increase in monocyte chemoattractant protein (MCP)‐1 expression upon HSV‐1 infection in TM cells (p
ISSN:	1582-1838 1582-4934
DOI:	10.1111/jcmm.16862