AcanR3990 qPCR: A Novel, Highly Sensitive, Bioinformatically-Informed Assay to Detect Angiostrongylus cantonensis Infections

AcanR3990 qPCR: A Novel, Highly Sensitive, Bioinformatically-Informed Assay to Detect Angiostrongylus cantonensis Infections

The AcanR3990 qPCR is designed to target repeated elements in the A. cantonensis genome, resulting in an assay with 100% specificity for human Angiostrongylus infection, improved clinical sensitivity, and the highest analytical sensitivity for A. cantonensis reported to date (1 fg).

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Veröffentlicht in:Clinical infectious diseases 2021-10, Vol.73 (7), p.e1594-e1600
Hauptverfasser: Sears, William J, Qvarnstrom, Yvonne, Dahlstrom, Eric, Snook, Kirsten, Kaluna, Lisa, Baláž, Vojtech, Feckova, Barbora, Šlapeta, Jan, Modry, David, Jarvi, Susan, Nutman, Thomas B
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Sprache:eng
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Zusammenfassung:The AcanR3990 qPCR is designed to target repeated elements in the A. cantonensis genome, resulting in an assay with 100% specificity for human Angiostrongylus infection, improved clinical sensitivity, and the highest analytical sensitivity for A. cantonensis reported to date (1 fg).
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciaa1791