Association between human coronaviruses’ epidemic and environmental factors on a global scale

Environmental factors could influence the epidemic of virus in human; however, the association remains intricate, and the evidence is still not clear in human coronaviruses (HCoVs). We aimed to explore and compare the associations between HCoVs’ epidemic and environmental factors globally. Four common HCoVs’ data were collected by a systematic literature review, and data of MERS, SARS, and COVID-19 were collected from the World Health Organization’s reports. Monthly positive rates of common HCoVs and incidence rates of MERS, SARS, and COVID-19 were calculated. Geographical coordinates were used to link virus data and environmental data. Generalized additive models (GAMs) were used to quantitatively estimate the association of environmental factors with HCoVs’ epidemic. We found that there are wide associations between HCoVs and environmental factors on a global scale, and some of the associations were nonlinear. In addition, COVID-19 has the most similarities in associations’ direction with common HCoVs, especially for HCoV-HKU1 in four environmental factors including the significantly negative associations with average temperature, precipitation, vegetation coverage ( p