Relatively low and moderate pre-fracture serum 25-hydroxyvitamin D levels associated with the highest survival in elderly hip fracture patients in Finland: a minimum 3-year follow-up
Summary The association between serum 25-hydroxyvitamin D level and post-fracture mortality indicates beneficial relatively high serum 25-hydroxyvitamin D concentrations. A 1-year cohort study on 245 hip fracture patients in Finland indicated the lowest 3-year mortality and highest survival among pa...
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| Veröffentlicht in: | Osteoporosis international 2022-03, Vol.33 (3), p.611-621 |
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| creator | Nurmi-Lüthje, I. Tiihonen, R. Paattiniemi, E-L. Sarkkinen, H. Naboulsi, H. Pigg, S. Kaukonen, J-P. Kataja, M. Lüthje, P. |
| description | Summary
The association between serum 25-hydroxyvitamin D level and post-fracture mortality indicates beneficial relatively high serum 25-hydroxyvitamin D concentrations. A 1-year cohort study on 245 hip fracture patients in Finland indicated the lowest 3-year mortality and highest survival among patients with serum 25-hydroxyvitamin D level of 50–74 nmol/L.
Purpose
To explore pre-fracture serum 25-hydroxyvitamin D level as a factor associated with post-fracture survival among a cohort of hip fracture patients in Finland.
Methods
A prospectively collected cohort of hip fracture patients (
n
= 245, 70% women) from two hospitals was followed for 3.2 post-hip fracture years. Serum 25-hydroxyvitamin D was measured in admission to the hospital and classified: |
| doi_str_mv | 10.1007/s00198-021-06094-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8481108</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2628403577</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-5f2aa9ad75a696e81a227fa06204d2c021beec8bd1941a1940a425039e7cab453</originalsourceid><addsrcrecordid>eNp9Uk1v1DAUjBCIbgt_gAOyxIWLwXacD3NAqgoFpEpICCRu1tvkZePKiYOdbNn-sP4-XtmyfBy42Ic3M2_mabLsiRQvpBDVyySENDUXSnJRCqP59b1sJXWec2XK4n62EiavuNHy61F2nNKlIJIx1cPsKNeFkTJXq-zmE3qY3Rb9jvlwxWBs2RBajDAjmyLyLkIzLxFZwrgMTBW837UxfN9t3QyDG9kb5pHoiUFKoXHEa9mVm3s298h6t-kxzSwtceu24BkR0JM8revdxA7qE5nAcU63gHM3evLxigGjBW6gtTnfIUTWBU8m-TI9yh504BM-vvtPsi_nbz-fvecXH999ODu94I2u9MyLTgEYaKsCSlNiLUGpqgNRKqFb1dDl1ohNvW4lXQnoEaBVIXKDVQNrXeQn2eu97rSsB2wbshjB2ym6AeLOBnD278noersJW1vrWkpRk8DzO4EYvi10Cju41KCngBiWZFVR1bLQWhuCPvsHehmWOFI8q0pVa5EXVUUotUc1MaQUsTuYkcLe1sLua2EpnP1ZC3tNpKd_xjhQfvWAAPkekGg0bjD-3v0f2R_HO8hj</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2628403577</pqid></control><display><type>article</type><title>Relatively low and moderate pre-fracture serum 25-hydroxyvitamin D levels associated with the highest survival in elderly hip fracture patients in Finland: a minimum 3-year follow-up</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Nurmi-Lüthje, I. ; Tiihonen, R. ; Paattiniemi, E-L. ; Sarkkinen, H. ; Naboulsi, H. ; Pigg, S. ; Kaukonen, J-P. ; Kataja, M. ; Lüthje, P.</creator><creatorcontrib>Nurmi-Lüthje, I. ; Tiihonen, R. ; Paattiniemi, E-L. ; Sarkkinen, H. ; Naboulsi, H. ; Pigg, S. ; Kaukonen, J-P. ; Kataja, M. ; Lüthje, P.</creatorcontrib><description>Summary
The association between serum 25-hydroxyvitamin D level and post-fracture mortality indicates beneficial relatively high serum 25-hydroxyvitamin D concentrations. A 1-year cohort study on 245 hip fracture patients in Finland indicated the lowest 3-year mortality and highest survival among patients with serum 25-hydroxyvitamin D level of 50–74 nmol/L.
Purpose
To explore pre-fracture serum 25-hydroxyvitamin D level as a factor associated with post-fracture survival among a cohort of hip fracture patients in Finland.
Methods
A prospectively collected cohort of hip fracture patients (
n
= 245, 70% women) from two hospitals was followed for 3.2 post-hip fracture years. Serum 25-hydroxyvitamin D was measured in admission to the hospital and classified: < 50, 50–74, 75–99, and ≥ 100 nmol/L. Survival was analyzed with a Bayesian multivariate model. Relative survival was explored with the life table method according to serum 25-hydroxyvitamin D. Mortality according to serum 25-hydroxyvitamin D level and to the hospital was calculated.
Results
Mortality in the patients with serum 25-hydroxyvitamin D level of 50–74 nmol/L was significantly lower than in all other patients together at every post-fracture year. The most important factors for survival were age under 85 years; living in an actual/private home; serum 25-hydroxyvitamin D level of 50–74 nmol/L, followed by 75–99 nmol/L; ASA classes 1–2 and 3; and female sex. The mean age of patients with serum 25-hydroxyvitamin D level of 50–99 nmol/L was significantly higher than in other levels. Relative survival was highest in men, women, and patients in hospital B with serum 25-hydroxyvitamin D level of 50–74 nmol.
Conclusion
The highest 3-year survival and the lowest mortality in this cohort appeared in patients with pre-fracture serum 25-hydroxyvitamin D level of 50–74 nmol/L. This result differs from similar studies and is lower than the recommended level of 25-hydroxyvitamin D among hip fracture patients. The results should be examined in future research with larger data.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-021-06094-z</identifier><identifier>PMID: 34591132</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>25-Hydroxyvitamin D ; Aged ; Aged, 80 and over ; Bayes Theorem ; Bayesian analysis ; Cohort Studies ; Endocrinology ; Female ; Finland - epidemiology ; Follow-Up Studies ; Fractures ; Hip ; Hip Fractures ; Humans ; Male ; Medicine ; Medicine & Public Health ; Mortality ; Older people ; Original ; Original Article ; Orthopedics ; Patients ; Rheumatology ; Survival ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D Deficiency - complications</subject><ispartof>Osteoporosis international, 2022-03, Vol.33 (3), p.611-621</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2021. corrected publication 2021</rights><rights>2021. International Osteoporosis Foundation and National Osteoporosis Foundation.</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2021. corrected publication 2021.</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2021, corrected publication 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-5f2aa9ad75a696e81a227fa06204d2c021beec8bd1941a1940a425039e7cab453</citedby><cites>FETCH-LOGICAL-c474t-5f2aa9ad75a696e81a227fa06204d2c021beec8bd1941a1940a425039e7cab453</cites><orcidid>0000-0002-9973-7752</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-021-06094-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-021-06094-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34591132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nurmi-Lüthje, I.</creatorcontrib><creatorcontrib>Tiihonen, R.</creatorcontrib><creatorcontrib>Paattiniemi, E-L.</creatorcontrib><creatorcontrib>Sarkkinen, H.</creatorcontrib><creatorcontrib>Naboulsi, H.</creatorcontrib><creatorcontrib>Pigg, S.</creatorcontrib><creatorcontrib>Kaukonen, J-P.</creatorcontrib><creatorcontrib>Kataja, M.</creatorcontrib><creatorcontrib>Lüthje, P.</creatorcontrib><title>Relatively low and moderate pre-fracture serum 25-hydroxyvitamin D levels associated with the highest survival in elderly hip fracture patients in Finland: a minimum 3-year follow-up</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
The association between serum 25-hydroxyvitamin D level and post-fracture mortality indicates beneficial relatively high serum 25-hydroxyvitamin D concentrations. A 1-year cohort study on 245 hip fracture patients in Finland indicated the lowest 3-year mortality and highest survival among patients with serum 25-hydroxyvitamin D level of 50–74 nmol/L.
Purpose
To explore pre-fracture serum 25-hydroxyvitamin D level as a factor associated with post-fracture survival among a cohort of hip fracture patients in Finland.
Methods
A prospectively collected cohort of hip fracture patients (
n
= 245, 70% women) from two hospitals was followed for 3.2 post-hip fracture years. Serum 25-hydroxyvitamin D was measured in admission to the hospital and classified: < 50, 50–74, 75–99, and ≥ 100 nmol/L. Survival was analyzed with a Bayesian multivariate model. Relative survival was explored with the life table method according to serum 25-hydroxyvitamin D. Mortality according to serum 25-hydroxyvitamin D level and to the hospital was calculated.
Results
Mortality in the patients with serum 25-hydroxyvitamin D level of 50–74 nmol/L was significantly lower than in all other patients together at every post-fracture year. The most important factors for survival were age under 85 years; living in an actual/private home; serum 25-hydroxyvitamin D level of 50–74 nmol/L, followed by 75–99 nmol/L; ASA classes 1–2 and 3; and female sex. The mean age of patients with serum 25-hydroxyvitamin D level of 50–99 nmol/L was significantly higher than in other levels. Relative survival was highest in men, women, and patients in hospital B with serum 25-hydroxyvitamin D level of 50–74 nmol.
Conclusion
The highest 3-year survival and the lowest mortality in this cohort appeared in patients with pre-fracture serum 25-hydroxyvitamin D level of 50–74 nmol/L. This result differs from similar studies and is lower than the recommended level of 25-hydroxyvitamin D among hip fracture patients. The results should be examined in future research with larger data.</description><subject>25-Hydroxyvitamin D</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bayes Theorem</subject><subject>Bayesian analysis</subject><subject>Cohort Studies</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Follow-Up Studies</subject><subject>Fractures</subject><subject>Hip</subject><subject>Hip Fractures</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Older people</subject><subject>Original</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Patients</subject><subject>Rheumatology</subject><subject>Survival</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D Deficiency - complications</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9Uk1v1DAUjBCIbgt_gAOyxIWLwXacD3NAqgoFpEpICCRu1tvkZePKiYOdbNn-sP4-XtmyfBy42Ic3M2_mabLsiRQvpBDVyySENDUXSnJRCqP59b1sJXWec2XK4n62EiavuNHy61F2nNKlIJIx1cPsKNeFkTJXq-zmE3qY3Rb9jvlwxWBs2RBajDAjmyLyLkIzLxFZwrgMTBW837UxfN9t3QyDG9kb5pHoiUFKoXHEa9mVm3s298h6t-kxzSwtceu24BkR0JM8revdxA7qE5nAcU63gHM3evLxigGjBW6gtTnfIUTWBU8m-TI9yh504BM-vvtPsi_nbz-fvecXH999ODu94I2u9MyLTgEYaKsCSlNiLUGpqgNRKqFb1dDl1ohNvW4lXQnoEaBVIXKDVQNrXeQn2eu97rSsB2wbshjB2ym6AeLOBnD278noersJW1vrWkpRk8DzO4EYvi10Cju41KCngBiWZFVR1bLQWhuCPvsHehmWOFI8q0pVa5EXVUUotUc1MaQUsTuYkcLe1sLua2EpnP1ZC3tNpKd_xjhQfvWAAPkekGg0bjD-3v0f2R_HO8hj</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Nurmi-Lüthje, I.</creator><creator>Tiihonen, R.</creator><creator>Paattiniemi, E-L.</creator><creator>Sarkkinen, H.</creator><creator>Naboulsi, H.</creator><creator>Pigg, S.</creator><creator>Kaukonen, J-P.</creator><creator>Kataja, M.</creator><creator>Lüthje, P.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9973-7752</orcidid></search><sort><creationdate>20220301</creationdate><title>Relatively low and moderate pre-fracture serum 25-hydroxyvitamin D levels associated with the highest survival in elderly hip fracture patients in Finland: a minimum 3-year follow-up</title><author>Nurmi-Lüthje, I. ; Tiihonen, R. ; Paattiniemi, E-L. ; Sarkkinen, H. ; Naboulsi, H. ; Pigg, S. ; Kaukonen, J-P. ; Kataja, M. ; Lüthje, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-5f2aa9ad75a696e81a227fa06204d2c021beec8bd1941a1940a425039e7cab453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bayes Theorem</topic><topic>Bayesian analysis</topic><topic>Cohort Studies</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>Follow-Up Studies</topic><topic>Fractures</topic><topic>Hip</topic><topic>Hip Fractures</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Older people</topic><topic>Original</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Patients</topic><topic>Rheumatology</topic><topic>Survival</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D Deficiency - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nurmi-Lüthje, I.</creatorcontrib><creatorcontrib>Tiihonen, R.</creatorcontrib><creatorcontrib>Paattiniemi, E-L.</creatorcontrib><creatorcontrib>Sarkkinen, H.</creatorcontrib><creatorcontrib>Naboulsi, H.</creatorcontrib><creatorcontrib>Pigg, S.</creatorcontrib><creatorcontrib>Kaukonen, J-P.</creatorcontrib><creatorcontrib>Kataja, M.</creatorcontrib><creatorcontrib>Lüthje, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nurmi-Lüthje, I.</au><au>Tiihonen, R.</au><au>Paattiniemi, E-L.</au><au>Sarkkinen, H.</au><au>Naboulsi, H.</au><au>Pigg, S.</au><au>Kaukonen, J-P.</au><au>Kataja, M.</au><au>Lüthje, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relatively low and moderate pre-fracture serum 25-hydroxyvitamin D levels associated with the highest survival in elderly hip fracture patients in Finland: a minimum 3-year follow-up</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>33</volume><issue>3</issue><spage>611</spage><epage>621</epage><pages>611-621</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
The association between serum 25-hydroxyvitamin D level and post-fracture mortality indicates beneficial relatively high serum 25-hydroxyvitamin D concentrations. A 1-year cohort study on 245 hip fracture patients in Finland indicated the lowest 3-year mortality and highest survival among patients with serum 25-hydroxyvitamin D level of 50–74 nmol/L.
Purpose
To explore pre-fracture serum 25-hydroxyvitamin D level as a factor associated with post-fracture survival among a cohort of hip fracture patients in Finland.
Methods
A prospectively collected cohort of hip fracture patients (
n
= 245, 70% women) from two hospitals was followed for 3.2 post-hip fracture years. Serum 25-hydroxyvitamin D was measured in admission to the hospital and classified: < 50, 50–74, 75–99, and ≥ 100 nmol/L. Survival was analyzed with a Bayesian multivariate model. Relative survival was explored with the life table method according to serum 25-hydroxyvitamin D. Mortality according to serum 25-hydroxyvitamin D level and to the hospital was calculated.
Results
Mortality in the patients with serum 25-hydroxyvitamin D level of 50–74 nmol/L was significantly lower than in all other patients together at every post-fracture year. The most important factors for survival were age under 85 years; living in an actual/private home; serum 25-hydroxyvitamin D level of 50–74 nmol/L, followed by 75–99 nmol/L; ASA classes 1–2 and 3; and female sex. The mean age of patients with serum 25-hydroxyvitamin D level of 50–99 nmol/L was significantly higher than in other levels. Relative survival was highest in men, women, and patients in hospital B with serum 25-hydroxyvitamin D level of 50–74 nmol.
Conclusion
The highest 3-year survival and the lowest mortality in this cohort appeared in patients with pre-fracture serum 25-hydroxyvitamin D level of 50–74 nmol/L. This result differs from similar studies and is lower than the recommended level of 25-hydroxyvitamin D among hip fracture patients. The results should be examined in future research with larger data.</abstract><cop>London</cop><pub>Springer London</pub><pmid>34591132</pmid><doi>10.1007/s00198-021-06094-z</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9973-7752</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-941X |
| ispartof | Osteoporosis international, 2022-03, Vol.33 (3), p.611-621 |
| issn | 0937-941X 1433-2965 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8481108 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 25-Hydroxyvitamin D Aged Aged, 80 and over Bayes Theorem Bayesian analysis Cohort Studies Endocrinology Female Finland - epidemiology Follow-Up Studies Fractures Hip Hip Fractures Humans Male Medicine Medicine & Public Health Mortality Older people Original Original Article Orthopedics Patients Rheumatology Survival Vitamin D Vitamin D - analogs & derivatives Vitamin D Deficiency - complications |
| title | Relatively low and moderate pre-fracture serum 25-hydroxyvitamin D levels associated with the highest survival in elderly hip fracture patients in Finland: a minimum 3-year follow-up |
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