Preoperative Breast MRI for Newly Diagnosed Ductal Carcinoma in Situ: Imaging Features and Performance in a Multicenter Setting (ECOG-ACRIN E4112 Trial)

Background There are limited data from clinical trials describing preoperative MRI features and performance in the evaluation of mammographically detected ductal carcinoma in situ (DCIS). Purpose To report qualitative MRI features of DCIS, MRI performance in the identification of additional disease,...

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Veröffentlicht in:Radiology 2021-10, Vol.301 (1), p.66-77
Hauptverfasser: Chou, Shinn-Huey S, Romanoff, Justin, Lehman, Constance D, Khan, Seema A, Carlos, Ruth, Badve, Sunil S, Xiao, Jennifer, Corsetti, Ralph L, Javid, Sara H, Spell, Derrick W, Han, Linda K, Sabol, Jennifer L, Bumberry, John R, Gareen, Ilana F, Snyder, Bradley S, Gatsonis, Constantine, Wagner, Lynne I, Wolff, Antonio C, Miller, Kathy D, Sparano, Joseph A, Comstock, Christopher E, Rahbar, Habib
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Sprache:eng
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Zusammenfassung:Background There are limited data from clinical trials describing preoperative MRI features and performance in the evaluation of mammographically detected ductal carcinoma in situ (DCIS). Purpose To report qualitative MRI features of DCIS, MRI performance in the identification of additional disease, and associations of imaging features with pathologic, genomic, and surgical outcomes from the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network (ECOG-ACRIN) E4112 trial. Materials and Methods Secondary analyses of a multicenter prospective clinical trial from the ECOG-ACRIN Cancer Research Group included women with DCIS diagnosed with conventional imaging techniques (mammography and US), confirmed via core-needle biopsy (CNB), and enrolled between March 2015 and April 2016 who were candidates for wide local excision (WLE) based on conventional imaging and clinical examination results. DCIS MRI features and pathologic features from CNB and excision were recorded. Each woman without invasive upgrade of the index DCIS at WLE received a 12-gene DCIS score. MRI performance metrics were calculated. Associations of imaging features with invasive upgrade, dichotomized DCIS score (
ISSN:0033-8419
1527-1315
DOI:10.1148/radiol.2021204743