Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV

Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV

Abstract The drivers of low-level viremia (LLV) between 20 and 200 copies/mL remain unclear. In 1042 person-visits from 497 persons with HIV on tenofovir disoproxil fumarate–containing antiretroviral therapy (ART), the association between LLV and cumulative antiretroviral adherence (quantified using...

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Veröffentlicht in:Open Forum Infectious Diseases 2021-09, Vol.8 (9), p.ofab463-ofab463
Hauptverfasser: Castillo-Mancilla, Jose R, Morrow, Mary, Coyle, Ryan P, Coleman, Stacey S, Zheng, Jia-Hua, Ellison, Lucas, Bushman, Lane R, Kiser, Jennifer J, Anderson, Peter L, MaWhinney, Samantha
Format: Artikel
Sprache:eng
Schlagworte:
Anti-HIV agents
Antiviral agents
Brief Reports
Ethylenediaminetetraacetic acid
Highly active antiretroviral therapy
HIV (Viruses)
HIV patients
Medical colleges
Patient compliance
Viremia
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Zusammenfassung:Abstract The drivers of low-level viremia (LLV) between 20 and 200 copies/mL remain unclear. In 1042 person-visits from 497 persons with HIV on tenofovir disoproxil fumarate–containing antiretroviral therapy (ART), the association between LLV and cumulative antiretroviral adherence (quantified using tenofovir diphosphate [TFV-DP] in dried blood spots) was assessed. Lower TFV-DP levels were associated with higher odds of LLV. As TFV-DP (fmol/punch) categories decreased from >1650 to 800–1650; 800–1650 to 1650 to
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofab463