HLA Alleles and Prognosis of PLA2R-Related Membranous Nephropathy

Associations between HLA alleles and susceptibility to M-type phospholipase A2 receptor (PLA2R)-related membranous nephropathy have been well defined previously in Chinese patients. However, the relationships between HLA alleles and kidney outcome remain unclear. Five HLA genes (DRB1, DQA1, DQB1, DR...

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Veröffentlicht in:	Clinical journal of the American Society of Nephrology 2021-08, Vol.16 (8), p.1221-1227
Hauptverfasser:	Le, Wei-Bo, Shi, Jing-Song, Fan, Yang, Gong, Si-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Asian People - genetics China Disease Progression Female Genotype Glomerular Filtration Rate Glomerulonephritis, Membranous - genetics Glomerulonephritis, Membranous - physiopathology HLA-DQ alpha-Chains - genetics HLA-DQ beta-Chains - genetics HLA-DR beta-Chains - genetics HLA-DRB1 Chains - genetics HLA-DRB3 Chains - genetics HLA-DRB5 Chains - genetics Humans Male Middle Aged Original Prognosis Prospective Studies Receptors, Phospholipase A2 - genetics Risk Factors
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Zusammenfassung:	Associations between HLA alleles and susceptibility to M-type phospholipase A2 receptor (PLA2R)-related membranous nephropathy have been well defined previously in Chinese patients. However, the relationships between HLA alleles and kidney outcome remain unclear. Five HLA genes (DRB1, DQA1, DQB1, DRB3, and DRB5) were genotyped in a prospective cohort of 392 patients with PLA2R-related membranous nephropathy. The associations between HLA alleles and kidney outcomes were studied. A total of 79 HLA alleles were identified in this study. Four HLA alleles, DRB1*13:01 ( =12; hazard ratio, 3.7; 95% confidence interval, 1.8 to 7.8;
ISSN:	1555-9041 1555-905X
DOI:	10.2215/CJN.18021120