Renal function in patients with significant tricuspid regurgitation: pathophysiological mechanisms and prognostic implications

Background The pathophysiological mechanisms linking tricuspid regurgitation (TR) and chronic kidney disease (CKD) remain unknown. This study aimed to determine which pathophysiological mechanisms related to TR are independently associated with renal dysfunction and to evaluate the impact of renal impairment on long‐term prognosis in patients with significant (≥ moderate) secondary TR. Methods A total of 1234 individuals (72 [IQR 63–78] years, 50% male) with significant secondary TR were followed up for the occurrence of all‐cause mortality and the presence of significant renal impairment (eGFR of