Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography
Objective The aim of this study was to evaluate the perifoveal and peripapillary microvascular structure in patients with Behçet’s disease (BD) without clinically ocular involvement. Methods Fifty-six eyes of 28 patients with Behçet’s disease without clinically ocular involvement and 50 age-matched...
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| creator | Karalezli, Aylin Kaderli, Sema Tamer Sul, Sabahattin Pektas, Suzan Demir |
| description | Objective
The aim of this study was to evaluate the perifoveal and peripapillary microvascular structure in patients with Behçet’s disease (BD) without clinically ocular involvement.
Methods
Fifty-six eyes of 28 patients with Behçet’s disease without clinically ocular involvement and 50 age-matched healthy eyes were included in this prospective study. Vessel densities (VD) of macula and optic nerve head, foveal avascular zone (FAZ), choroid capillary plexus (CCP) flow area, perifoveal capillary nonperfusion, capillary dilatation and/or telangiectasia and perifoveal capillary arcade disruption were analyzed with optical coherence tomography angiography (OCTA). The relationship between duration of disease and vessel densities was also evaluated.
Results
The FAZ was significantly higher in the BD group (
p
|
| doi_str_mv | 10.1038/s41433-020-01294-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8452614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2464192124</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-c497d51ea5b62935338c4207eea2196af034ac69892b92e3287cc8f1c7de58203</originalsourceid><addsrcrecordid>eNp9kU1uFDEQhS1ERIaBC7BAltiwaWKX7f7ZIJGIPylSWIDEzvK4q6cd9bQb2w2arHKNnICDcBNOgpMZEmDBxrb0vnpV5UfIE85ecCbqoyi5FKJgwArGoZHFxT2y4LIqCyWVvE8WrFGsAIDPh-RhjOeMZbFiD8ihECCUkGxB5g8B7eBGZ81AvZ0HE2iHJs0BI3UjnUxyOKZIv7nU02Psf3zH9PPyKtLWRTQRaYsJbcKWrrbUT-nGyPoeA44WafIbvw5m6rfUjGu3fz8iB50ZIj7e30vy6c3rjyfvitOzt-9PXp0WVlYy5bOpWsXRqFUJTZ5Y1FYCqxAN8KY0HRPS2LKpG1g1gALqytq647ZqUdXAxJK83PlO82qDrc2bBDPoKbiNCVvtjdN_K6Pr9dp_1bVUUObfXZLne4Pgv8wYk964aHEYzIh-jhpkKXkDHK7RZ_-g534OY15Pg6qkUqoqRaZgR9ngYwzY3Q7Dmb5OVe9S1TlVfZOqvshFT_9c47bkd4wZEDsgZmlcY7jr_R_bXze7shE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2574555763</pqid></control><display><type>article</type><title>Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography</title><source>MEDLINE</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Karalezli, Aylin ; Kaderli, Sema Tamer ; Sul, Sabahattin ; Pektas, Suzan Demir</creator><creatorcontrib>Karalezli, Aylin ; Kaderli, Sema Tamer ; Sul, Sabahattin ; Pektas, Suzan Demir</creatorcontrib><description><![CDATA[Objective
The aim of this study was to evaluate the perifoveal and peripapillary microvascular structure in patients with Behçet’s disease (BD) without clinically ocular involvement.
Methods
Fifty-six eyes of 28 patients with Behçet’s disease without clinically ocular involvement and 50 age-matched healthy eyes were included in this prospective study. Vessel densities (VD) of macula and optic nerve head, foveal avascular zone (FAZ), choroid capillary plexus (CCP) flow area, perifoveal capillary nonperfusion, capillary dilatation and/or telangiectasia and perifoveal capillary arcade disruption were analyzed with optical coherence tomography angiography (OCTA). The relationship between duration of disease and vessel densities was also evaluated.
Results
The FAZ was significantly higher in the BD group (
p
< 0.001). VD of the foveal and parafoveal region in deep capillary plexus (DCP) were significantly lower in the BD group than in the control group (
p
< 0.001,
p
< 0.001). Total disc, peripapillary and inside-disc VD were significantly lower in BD group (
p
= 0.001,
p
= 0.002,
p
= 0.004). Perifoveal morphological changes in DCP were significantly higher in nonocular BD (
p
< 0.001,
p
< 0.001,
p
< 0.001). There was a mild negative correlation between disease duration and whole VD in DCP, total disc VD, peripapillary VD was determined (For whole VD in DCP,
r
= −0.400,
p
= 0.035; for total disc VD
r
= −0.396,
p
= 0.037; for peripapillary VD
r
= −0.442,
p
= 0.018).
Discussion
Perifoveal and peripapillary microvascular changes that can be detected by OCTA may occur in Behçet’s patients without clinically ocular involvement.]]></description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/s41433-020-01294-z</identifier><identifier>PMID: 33235340</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/249 ; 692/1807/1482 ; Angiography ; Behcet Syndrome - diagnostic imaging ; Behcet's syndrome ; Eye ; Fluorescein Angiography ; Humans ; Laboratory Medicine ; Medical imaging ; Medicine ; Medicine & Public Health ; Microvasculature ; Ophthalmology ; Optic nerve ; Pharmaceutical Sciences/Technology ; Prospective Studies ; Retinal Vessels - diagnostic imaging ; Sexually transmitted diseases ; STD ; Surgery ; Surgical Oncology ; Tomography ; Tomography, Optical Coherence ; Vein & artery diseases</subject><ispartof>Eye (London), 2021-10, Vol.35 (10), p.2719-2726</ispartof><rights>The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2020</rights><rights>2020. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.</rights><rights>The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-c497d51ea5b62935338c4207eea2196af034ac69892b92e3287cc8f1c7de58203</citedby><cites>FETCH-LOGICAL-c474t-c497d51ea5b62935338c4207eea2196af034ac69892b92e3287cc8f1c7de58203</cites><orcidid>0000-0003-4851-6527</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452614/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8452614/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33235340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karalezli, Aylin</creatorcontrib><creatorcontrib>Kaderli, Sema Tamer</creatorcontrib><creatorcontrib>Sul, Sabahattin</creatorcontrib><creatorcontrib>Pektas, Suzan Demir</creatorcontrib><title>Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description><![CDATA[Objective
The aim of this study was to evaluate the perifoveal and peripapillary microvascular structure in patients with Behçet’s disease (BD) without clinically ocular involvement.
Methods
Fifty-six eyes of 28 patients with Behçet’s disease without clinically ocular involvement and 50 age-matched healthy eyes were included in this prospective study. Vessel densities (VD) of macula and optic nerve head, foveal avascular zone (FAZ), choroid capillary plexus (CCP) flow area, perifoveal capillary nonperfusion, capillary dilatation and/or telangiectasia and perifoveal capillary arcade disruption were analyzed with optical coherence tomography angiography (OCTA). The relationship between duration of disease and vessel densities was also evaluated.
Results
The FAZ was significantly higher in the BD group (
p
< 0.001). VD of the foveal and parafoveal region in deep capillary plexus (DCP) were significantly lower in the BD group than in the control group (
p
< 0.001,
p
< 0.001). Total disc, peripapillary and inside-disc VD were significantly lower in BD group (
p
= 0.001,
p
= 0.002,
p
= 0.004). Perifoveal morphological changes in DCP were significantly higher in nonocular BD (
p
< 0.001,
p
< 0.001,
p
< 0.001). There was a mild negative correlation between disease duration and whole VD in DCP, total disc VD, peripapillary VD was determined (For whole VD in DCP,
r
= −0.400,
p
= 0.035; for total disc VD
r
= −0.396,
p
= 0.037; for peripapillary VD
r
= −0.442,
p
= 0.018).
Discussion
Perifoveal and peripapillary microvascular changes that can be detected by OCTA may occur in Behçet’s patients without clinically ocular involvement.]]></description><subject>631/250/249</subject><subject>692/1807/1482</subject><subject>Angiography</subject><subject>Behcet Syndrome - diagnostic imaging</subject><subject>Behcet's syndrome</subject><subject>Eye</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microvasculature</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Prospective Studies</subject><subject>Retinal Vessels - diagnostic imaging</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence</subject><subject>Vein & artery diseases</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1uFDEQhS1ERIaBC7BAltiwaWKX7f7ZIJGIPylSWIDEzvK4q6cd9bQb2w2arHKNnICDcBNOgpMZEmDBxrb0vnpV5UfIE85ecCbqoyi5FKJgwArGoZHFxT2y4LIqCyWVvE8WrFGsAIDPh-RhjOeMZbFiD8ihECCUkGxB5g8B7eBGZ81AvZ0HE2iHJs0BI3UjnUxyOKZIv7nU02Psf3zH9PPyKtLWRTQRaYsJbcKWrrbUT-nGyPoeA44WafIbvw5m6rfUjGu3fz8iB50ZIj7e30vy6c3rjyfvitOzt-9PXp0WVlYy5bOpWsXRqFUJTZ5Y1FYCqxAN8KY0HRPS2LKpG1g1gALqytq647ZqUdXAxJK83PlO82qDrc2bBDPoKbiNCVvtjdN_K6Pr9dp_1bVUUObfXZLne4Pgv8wYk964aHEYzIh-jhpkKXkDHK7RZ_-g534OY15Pg6qkUqoqRaZgR9ngYwzY3Q7Dmb5OVe9S1TlVfZOqvshFT_9c47bkd4wZEDsgZmlcY7jr_R_bXze7shE</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Karalezli, Aylin</creator><creator>Kaderli, Sema Tamer</creator><creator>Sul, Sabahattin</creator><creator>Pektas, Suzan Demir</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4851-6527</orcidid></search><sort><creationdate>20211001</creationdate><title>Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography</title><author>Karalezli, Aylin ; Kaderli, Sema Tamer ; Sul, Sabahattin ; Pektas, Suzan Demir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-c497d51ea5b62935338c4207eea2196af034ac69892b92e3287cc8f1c7de58203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/250/249</topic><topic>692/1807/1482</topic><topic>Angiography</topic><topic>Behcet Syndrome - diagnostic imaging</topic><topic>Behcet's syndrome</topic><topic>Eye</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Laboratory Medicine</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microvasculature</topic><topic>Ophthalmology</topic><topic>Optic nerve</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Prospective Studies</topic><topic>Retinal Vessels - diagnostic imaging</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karalezli, Aylin</creatorcontrib><creatorcontrib>Kaderli, Sema Tamer</creatorcontrib><creatorcontrib>Sul, Sabahattin</creatorcontrib><creatorcontrib>Pektas, Suzan Demir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karalezli, Aylin</au><au>Kaderli, Sema Tamer</au><au>Sul, Sabahattin</au><au>Pektas, Suzan Demir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>35</volume><issue>10</issue><spage>2719</spage><epage>2726</epage><pages>2719-2726</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract><![CDATA[Objective
The aim of this study was to evaluate the perifoveal and peripapillary microvascular structure in patients with Behçet’s disease (BD) without clinically ocular involvement.
Methods
Fifty-six eyes of 28 patients with Behçet’s disease without clinically ocular involvement and 50 age-matched healthy eyes were included in this prospective study. Vessel densities (VD) of macula and optic nerve head, foveal avascular zone (FAZ), choroid capillary plexus (CCP) flow area, perifoveal capillary nonperfusion, capillary dilatation and/or telangiectasia and perifoveal capillary arcade disruption were analyzed with optical coherence tomography angiography (OCTA). The relationship between duration of disease and vessel densities was also evaluated.
Results
The FAZ was significantly higher in the BD group (
p
< 0.001). VD of the foveal and parafoveal region in deep capillary plexus (DCP) were significantly lower in the BD group than in the control group (
p
< 0.001,
p
< 0.001). Total disc, peripapillary and inside-disc VD were significantly lower in BD group (
p
= 0.001,
p
= 0.002,
p
= 0.004). Perifoveal morphological changes in DCP were significantly higher in nonocular BD (
p
< 0.001,
p
< 0.001,
p
< 0.001). There was a mild negative correlation between disease duration and whole VD in DCP, total disc VD, peripapillary VD was determined (For whole VD in DCP,
r
= −0.400,
p
= 0.035; for total disc VD
r
= −0.396,
p
= 0.037; for peripapillary VD
r
= −0.442,
p
= 0.018).
Discussion
Perifoveal and peripapillary microvascular changes that can be detected by OCTA may occur in Behçet’s patients without clinically ocular involvement.]]></abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33235340</pmid><doi>10.1038/s41433-020-01294-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4851-6527</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-222X |
| ispartof | Eye (London), 2021-10, Vol.35 (10), p.2719-2726 |
| issn | 0950-222X 1476-5454 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8452614 |
| source | MEDLINE; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | 631/250/249 692/1807/1482 Angiography Behcet Syndrome - diagnostic imaging Behcet's syndrome Eye Fluorescein Angiography Humans Laboratory Medicine Medical imaging Medicine Medicine & Public Health Microvasculature Ophthalmology Optic nerve Pharmaceutical Sciences/Technology Prospective Studies Retinal Vessels - diagnostic imaging Sexually transmitted diseases STD Surgery Surgical Oncology Tomography Tomography, Optical Coherence Vein & artery diseases |
| title | Preclinical ocular features in patients with Behçet’s disease detected by optical coherence tomography angiography |
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