Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model (  = 48) and two prospective clinical studies (PROVIDE [  = 263] and CAMERA2 [  = 291]). A logit-link model was used to calculate the multiplicati...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Antimicrobial agents and chemotherapy 2021-09, Vol.65 (10), p.e0106021-e0106021
Hauptverfasser:	Scheetz, Marc H, Pais, Gwendolyn M, Lodise, Thomas P, Tong, Steven Y C, Davis, Joshua S, O'Donnell, J Nicholas, Liu, Jiajun, Neely, Michael, Prozialeck, Walter C, Lamar, Peter C, Rhodes, Nathaniel J, Holland, Thomas, Avedissian, Sean N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - drug therapy Animals Anti-Bacterial Agents - adverse effects Antimicrobial Chemotherapy Area Under Curve Pharmacology Prospective Studies Rats Vancomycin - adverse effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!