Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model ( = 48) and two prospective clinical studies (PROVIDE [ = 263] and CAMERA2 [ = 291]). A logit-link model was used to calculate the multiplicati...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2021-09, Vol.65 (10), p.e0106021-e0106021
Hauptverfasser:	Scheetz, Marc H, Pais, Gwendolyn M, Lodise, Thomas P, Tong, Steven Y C, Davis, Joshua S, O'Donnell, J Nicholas, Liu, Jiajun, Neely, Michael, Prozialeck, Walter C, Lamar, Peter C, Rhodes, Nathaniel J, Holland, Thomas, Avedissian, Sean N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - drug therapy Animals Anti-Bacterial Agents - adverse effects Antimicrobial Chemotherapy Area Under Curve Pharmacology Prospective Studies Rats Vancomycin - adverse effects
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Beschreibung
Zusammenfassung:	Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model ( = 48) and two prospective clinical studies (PROVIDE [ = 263] and CAMERA2 [ = 291]). A logit-link model was used to calculate the multiplicative factors between the probability of AKI from clinical studies and in the rat. The rat was 2.7 to 4.2 times more sensitive to AKI between AUCs of 199.5 and 794.3 mg·h/liter, respectively.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.01060-21