High-Sensitivity C-Reactive Protein Modifies the Cardiovascular Risk of Lipoprotein(a): Multi-Ethnic Study of Atherosclerosis

Little is known about the relationship between lipoprotein (a) [Lp(a)] and high-sensitivity C-reactive protein (hsCRP) and their joint association with atherosclerotic cardiovascular disease (ASCVD). The purpose of this study was to assess whether Lp(a)-associated ASCVD risk is modified by hsCRP in...

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Veröffentlicht in:	Journal of the American College of Cardiology 2021-09, Vol.78 (11), p.1083-1094
Hauptverfasser:	Zhang, Wei, Speiser, Jaime Lynn, Ye, Fan, Tsai, Michael Y, Cainzos-Achirica, Miguel, Nasir, Khurram, Herrington, David M, Shapiro, Michael D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Atherosclerosis - blood Atherosclerosis - ethnology C-Reactive Protein - metabolism Cohort Studies Female Heart Disease Risk Factors Humans Lipoprotein(a) - blood Male Middle Aged Mortality United States - epidemiology
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Zusammenfassung:	Little is known about the relationship between lipoprotein (a) [Lp(a)] and high-sensitivity C-reactive protein (hsCRP) and their joint association with atherosclerotic cardiovascular disease (ASCVD). The purpose of this study was to assess whether Lp(a)-associated ASCVD risk is modified by hsCRP in the context of primary prevention. The current study included 4,679 participants from the MESA (Multi-Ethnic Study of Atherosclerosis) Apolipoprotein ancillary data set. Cox proportional hazards models and Kaplan-Meier curves were used to assess the association among Lp(a), hsCRP, and time to cardiovascular disease (CVD) events. During a mean follow-up of 13.6 years, 684 CVD events occurred. A significant interaction was observed between Lp(a) and hsCRP (P = 0.04). With hsCRP
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2021.07.016