An inflammatory switch for stem cell plasticity

An inflammatory switch for stem cell plasticity

Tissue-resident stem cells are capable of remarkable plasticity in areas of tissue damage, where inflammatory cells accumulate as part of the reparative response. A study in the lung now provides critical insight on how inflammatory signals alter cell-to-cell Notch signalling within the airway niche...

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Veröffentlicht in:Nature cell biology 2021-09, Vol.23 (9), p.928-929
Hauptverfasser: Kathiriya, Jaymin J., Peng, Tien
Format: Artikel
Sprache:eng
Schlagworte:
631/532/2139
631/80/86
Biomedical and Life Sciences
Cancer Research
Cell Biology
Cell Differentiation
Cell Plasticity
Damage accumulation
Developmental Biology
Inflammation
Life Sciences
News & Views
news-and-views
Physiological aspects
Plastic properties
Plasticity
Properties
Stem Cells
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Beschreibung
Zusammenfassung:Tissue-resident stem cells are capable of remarkable plasticity in areas of tissue damage, where inflammatory cells accumulate as part of the reparative response. A study in the lung now provides critical insight on how inflammatory signals alter cell-to-cell Notch signalling within the airway niche to drive stem cell plasticity.
ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-021-00752-4