Lessons of the month 1: Longitudinal extensive transverse myelitis following AstraZeneca COVID-19 vaccination
Longitudinal extensive transverse myelitis (LETM) is a rare but recognised complication of vaccination. We report the case of a 58-year-old man admitted to hospital 10 days after his first AstraZeneca COVID-19 vaccination with progressive neurological symptoms and signs, and investigations and imagi...
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Veröffentlicht in: | Clinical medicine (London, England) England), 2021-09, Vol.21 (5), p.e535-e538 |
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creator | Notghi, Alp AA Atley, Joseph Silva, Mark |
description | Longitudinal extensive transverse myelitis (LETM) is a rare but recognised complication of vaccination. We report the case of a 58-year-old man admitted to hospital 10 days after his first AstraZeneca COVID-19 vaccination with progressive neurological symptoms and signs, and investigations and imaging consistent with LETM.
This case reviews the literature and the investigative process behind excluding other diagnoses given the patient’s background of pulmonary sarcoidosis. It is unique in being the first UK report of a case of LETM with a strong temporal link to COVID-19 vaccination. |
doi_str_mv | 10.7861/clinmed.2021-0470 |
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This case reviews the literature and the investigative process behind excluding other diagnoses given the patient’s background of pulmonary sarcoidosis. It is unique in being the first UK report of a case of LETM with a strong temporal link to COVID-19 vaccination.</description><identifier>ISSN: 1470-2118</identifier><identifier>EISSN: 1473-4893</identifier><identifier>DOI: 10.7861/clinmed.2021-0470</identifier><identifier>PMID: 34507942</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>AstraZeneca ; Coronaviruses ; COVID-19 ; COVID-19 Vaccines ; Diabetes ; Humans ; Influenza ; Lessons of the Month ; longitudinal extensive transverse myelitis ; Magnetic resonance imaging ; Male ; Middle Aged ; Multiple sclerosis ; myelitis ; Myelitis, Transverse - chemically induced ; Myelitis, Transverse - drug therapy ; Sarcoidosis ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Steroids ; vaccination ; Vaccination - adverse effects</subject><ispartof>Clinical medicine (London, England), 2021-09, Vol.21 (5), p.e535-e538</ispartof><rights>2021 © 2021 THE AUTHORS. Published by Elsevier Limited on behalf of the Royal College of Physicians.</rights><rights>Royal College of Physicians 2021. All rights reserved.</rights><rights>Copyright Royal College of Physicians Sep 2021</rights><rights>Royal College of Physicians 2021. All rights reserved. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-4c750ebda01ca2066cfbd38ae3c127ebf914eda2f42d246454dc75488321b7083</citedby><cites>FETCH-LOGICAL-c545t-4c750ebda01ca2066cfbd38ae3c127ebf914eda2f42d246454dc75488321b7083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439525/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439525/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34507942$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Notghi, Alp AA</creatorcontrib><creatorcontrib>Atley, Joseph</creatorcontrib><creatorcontrib>Silva, Mark</creatorcontrib><title>Lessons of the month 1: Longitudinal extensive transverse myelitis following AstraZeneca COVID-19 vaccination</title><title>Clinical medicine (London, England)</title><addtitle>Clin Med (Lond)</addtitle><description>Longitudinal extensive transverse myelitis (LETM) is a rare but recognised complication of vaccination. We report the case of a 58-year-old man admitted to hospital 10 days after his first AstraZeneca COVID-19 vaccination with progressive neurological symptoms and signs, and investigations and imaging consistent with LETM.
This case reviews the literature and the investigative process behind excluding other diagnoses given the patient’s background of pulmonary sarcoidosis. It is unique in being the first UK report of a case of LETM with a strong temporal link to COVID-19 vaccination.</description><subject>AstraZeneca</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 Vaccines</subject><subject>Diabetes</subject><subject>Humans</subject><subject>Influenza</subject><subject>Lessons of the Month</subject><subject>longitudinal extensive transverse myelitis</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>myelitis</subject><subject>Myelitis, Transverse - chemically induced</subject><subject>Myelitis, Transverse - drug therapy</subject><subject>Sarcoidosis</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Steroids</subject><subject>vaccination</subject><subject>Vaccination - adverse effects</subject><issn>1470-2118</issn><issn>1473-4893</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kV9rFDEUxYNYbK1-AF8k4PPU_J3MKAhl1baw0Bf1wZeQSe7spswmNcmO7bc3666lffEpF-45J5fzQ-gNJWeqa-l7O_mwAXfGCKMNEYo8QydUKN6IrufP_86kYZR2x-hlzjeEUCn69gU65kIS1Qt2gjZLyDmGjOOIyxrwJoayxvQDXsaw8mXrfDAThrsCIfsZcEkm5BlSrtJ7mHzxGY9xmuJvH1b4PNf9TwhgDV5c_7j63NAez8bamlJ8DK_Q0WimDK8P7yn6_vXLt8Vls7y-uFqcLxsrhSyNsEoSGJwh1BpG2taOg-OdAW4pUzCMPRXgDBsFc0y0QgpXHaLrOKODIh0_RZ_2ubfboRZkIdS7Jn2b_Makex2N1083wa_1Ks66E7yXTNaAd4eAFH9tIRd9E7epVpE1k6pVhLScVxXdq2yKOScYH36gRO8I6QMhvSOkd4Sq5-3j0x4c_5BUwce9AGpBs4eks_UQLDifwBbtov9P_B_bV6ST</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Notghi, Alp AA</creator><creator>Atley, Joseph</creator><creator>Silva, Mark</creator><general>Elsevier Ltd</general><general>Royal College of Physicians</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>202109</creationdate><title>Lessons of the month 1: Longitudinal extensive transverse myelitis following AstraZeneca COVID-19 vaccination</title><author>Notghi, Alp AA ; Atley, Joseph ; Silva, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-4c750ebda01ca2066cfbd38ae3c127ebf914eda2f42d246454dc75488321b7083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>AstraZeneca</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 Vaccines</topic><topic>Diabetes</topic><topic>Humans</topic><topic>Influenza</topic><topic>Lessons of the Month</topic><topic>longitudinal extensive transverse myelitis</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>myelitis</topic><topic>Myelitis, Transverse - chemically induced</topic><topic>Myelitis, Transverse - drug therapy</topic><topic>Sarcoidosis</topic><topic>SARS-CoV-2</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Steroids</topic><topic>vaccination</topic><topic>Vaccination - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Notghi, Alp AA</creatorcontrib><creatorcontrib>Atley, Joseph</creatorcontrib><creatorcontrib>Silva, Mark</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical medicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Notghi, Alp AA</au><au>Atley, Joseph</au><au>Silva, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lessons of the month 1: Longitudinal extensive transverse myelitis following AstraZeneca COVID-19 vaccination</atitle><jtitle>Clinical medicine (London, England)</jtitle><addtitle>Clin Med (Lond)</addtitle><date>2021-09</date><risdate>2021</risdate><volume>21</volume><issue>5</issue><spage>e535</spage><epage>e538</epage><pages>e535-e538</pages><issn>1470-2118</issn><eissn>1473-4893</eissn><abstract>Longitudinal extensive transverse myelitis (LETM) is a rare but recognised complication of vaccination. We report the case of a 58-year-old man admitted to hospital 10 days after his first AstraZeneca COVID-19 vaccination with progressive neurological symptoms and signs, and investigations and imaging consistent with LETM.
This case reviews the literature and the investigative process behind excluding other diagnoses given the patient’s background of pulmonary sarcoidosis. It is unique in being the first UK report of a case of LETM with a strong temporal link to COVID-19 vaccination.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>34507942</pmid><doi>10.7861/clinmed.2021-0470</doi><oa>free_for_read</oa></addata></record> |
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subjects | AstraZeneca Coronaviruses COVID-19 COVID-19 Vaccines Diabetes Humans Influenza Lessons of the Month longitudinal extensive transverse myelitis Magnetic resonance imaging Male Middle Aged Multiple sclerosis myelitis Myelitis, Transverse - chemically induced Myelitis, Transverse - drug therapy Sarcoidosis SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Steroids vaccination Vaccination - adverse effects |
title | Lessons of the month 1: Longitudinal extensive transverse myelitis following AstraZeneca COVID-19 vaccination |
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