Lessons of the month 1: Longitudinal extensive transverse myelitis following AstraZeneca COVID-19 vaccination

Longitudinal extensive transverse myelitis (LETM) is a rare but recognised complication of vaccination. We report the case of a 58-year-old man admitted to hospital 10 days after his first AstraZeneca COVID-19 vaccination with progressive neurological symptoms and signs, and investigations and imagi...

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Veröffentlicht in:	Clinical medicine (London, England) England), 2021-09, Vol.21 (5), p.e535-e538
Hauptverfasser:	Notghi, Alp AA, Atley, Joseph, Silva, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	AstraZeneca Coronaviruses COVID-19 COVID-19 Vaccines Diabetes Humans Influenza Lessons of the Month longitudinal extensive transverse myelitis Magnetic resonance imaging Male Middle Aged Multiple sclerosis myelitis Myelitis, Transverse - chemically induced Myelitis, Transverse - drug therapy Sarcoidosis SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Steroids vaccination Vaccination - adverse effects
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Beschreibung
Zusammenfassung:	Longitudinal extensive transverse myelitis (LETM) is a rare but recognised complication of vaccination. We report the case of a 58-year-old man admitted to hospital 10 days after his first AstraZeneca COVID-19 vaccination with progressive neurological symptoms and signs, and investigations and imaging consistent with LETM. This case reviews the literature and the investigative process behind excluding other diagnoses given the patient’s background of pulmonary sarcoidosis. It is unique in being the first UK report of a case of LETM with a strong temporal link to COVID-19 vaccination.
ISSN:	1470-2118 1473-4893
DOI:	10.7861/clinmed.2021-0470