Myeloma-bone marrow adipocyte axis in tumour survival and treatment response

Summary Multiple myeloma is an incurable cancer of the bone marrow that is dependent on its microenvironment, including bone marrow adipocytes (BMAds). Here, we discuss our findings that the reciprocal interaction of myeloma cells and BMAds, leads to myeloma cell survival and induces metabolic dysfu...

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Veröffentlicht in:	British journal of cancer 2021-09, Vol.125 (6), p.775-777
Hauptverfasser:	Jafari, Abbas, Fairfield, Heather, Andersen, Thomas L., Reagan, Michaela R.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/2019 631/80/304 692/308/2778 692/699/67/1990/804 Adipocytes Adipocytes - metabolism Adipocytes - pathology Biomedical and Life Sciences Biomedicine Blood cancer Bone cancer Bone marrow Bone Marrow - metabolism Bone Marrow - pathology Cancer Research Cell Survival Comment Drug Resistance Epidemiology Humans Metabolic Networks and Pathways Microenvironments Molecular Medicine Multiple myeloma Multiple Myeloma - metabolism Multiple Myeloma - pathology Oncology Phenotypes Senescence Tumor Microenvironment Tumors
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Zusammenfassung:	Summary Multiple myeloma is an incurable cancer of the bone marrow that is dependent on its microenvironment, including bone marrow adipocytes (BMAds). Here, we discuss our findings that the reciprocal interaction of myeloma cells and BMAds, leads to myeloma cell survival and induces metabolic dysfunction and senescence-associated secretory phenotype in BMAds.
ISSN:	0007-0920 1532-1827
DOI:	10.1038/s41416-021-01371-4