Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life

Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life

Background The first 6 months of life are a critical window for adiposity programming. Appetite-regulating hormones (ARH) are involved in food intake regulation and might, therefore, play a role in adiposity programming. Studies examining ARH in early life are limited. Purpose To investigate ghrelin...

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Veröffentlicht in:European journal of nutrition 2021-10, Vol.60 (7), p.3717-3725
Hauptverfasser: de Fluiter, Kirsten S., Kerkhof, Gerthe F., van Beijsterveldt, Inge A. L. P., Breij, Laura M., van Vark-van der Zee, Leonie C., Mulder, Monique T., Abrahamse-Berkeveld, Marieke, Hokken-Koelega, Anita C. S.
Format: Artikel
Sprache:eng
Schlagworte:
Adipose tissue
Adiposity
Appetite
Babies
Body composition
Body fat
Breast feeding
Breast milk
Breastfeeding & lactation
Chemistry
Chemistry and Materials Science
Female
Food intake
Ghrelin
Ghrelin - physiology
Humans
Infant
Infant, Newborn
Infants
Leptin
Leptin - physiology
Milk, Human
Nutrients
Nutrition
Original Contribution
Peptide YY
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Zusammenfassung:Background The first 6 months of life are a critical window for adiposity programming. Appetite-regulating hormones (ARH) are involved in food intake regulation and might, therefore, play a role in adiposity programming. Studies examining ARH in early life are limited. Purpose To investigate ghrelin, peptide YY (PYY) and leptin until 6 months and associations with fat mass percentage (FM%), infant feeding and human milk macronutrients. Procedures In 297 term-born infants (Sophia Pluto Cohort), ghrelin (acylated), PYY and leptin were determined at 3 and 6 months, with FM% measurement by PEAPOD. Exclusive breastfeeding (BF) was classified as BF ≥ 3 months. Human milk macronutrients were analyzed (MIRIS Human Milk Analyzer). Main findings Ghrelin increased from 3 to 6 months ( p  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-021-02533-z