The association between sarcopenia and endotoxin in patients with alcoholic cirrhosis

The association between sarcopenia and endotoxin in patients with alcoholic cirrhosis

We aimed to prospectively identify the risk factors of sarcopenia in patients with cirrhosis.Patients (n = 193) included in a discovery cohort (January 2011 and December 2014) were categorized into alcoholic (A1; n = 55) and non-alcoholic cirrhosis (NA; n = 138) groups, and those (n = 235) in a vali...

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Veröffentlicht in:Medicine (Baltimore) 2021-09, Vol.100 (36), p.e27212-e27212
Hauptverfasser: Sato, Shinya, Namisaki, Tadashi, Murata, Koji, Fujimoto, Yuki, Takeda, Soichi, Enomoto, Masahide, Shibamoto, Akihiko, Ishida, Koji, Ogawa, Hiroyuki, Takagi, Hirotetsu, Tsuji, Yuki, Kaya, Daisuke, Fujinaga, Yukihisa, Furukawa, Masanori, Inoue, Takashi, Sawada, Yasuhiko, Nishimura, Norihisa, Kitagawa, Koh, Ozutsumi, Takahiro, Takaya, Hiroaki, Kaji, Kosuke, Shimozato, Naotaka, Kawaratani, Hideto, Moriya, Kei, Akahane, Takemi, Mitoro, Akira, Yoshiji, Hitoshi
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Cohort Studies
Endotoxins - metabolism
Female
Humans
Japan - epidemiology
Liver Cirrhosis, Alcoholic
Male
Muscle, Skeletal - metabolism
Observational Study
Prevalence
Retrospective Studies
Risk Factors
Sarcopenia - diagnostic imaging
Sarcopenia - epidemiology
Sarcopenia - etiology
Tomography, X-Ray Computed
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Zusammenfassung:We aimed to prospectively identify the risk factors of sarcopenia in patients with cirrhosis.Patients (n = 193) included in a discovery cohort (January 2011 and December 2014) were categorized into alcoholic (A1; n = 55) and non-alcoholic cirrhosis (NA; n = 138) groups, and those (n = 235) in a validation cohort (January 2015 to December 2019) were categorized into alcoholic (n = 92), non-alcoholic steatohepatitis-related (n = 27), and hepatitis C virus-related cirrhosis groups (n = 116). Skeletal muscle mass index (SMI) was determined using computed tomography (SMI-CT) and bioelectrical impedance analysis (SMI-BIA). Endotoxin activity (EA) was measured with an EA assay.SMI-CT correlated with grip strength in all the groups but significantly correlated with SMI-BIA of the men in group A1 (R = 0.64, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000027212