Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting

Among more than 1.7 million persons, BNT162b2 vaccination was associated with increased risks of myocarditis (risk ratio, 3.24), lymphadenopathy, appendicitis, and herpes zoster infection; in comparison, Covid-19 increased the risks of myocarditis (risk ratio, 18.28), pericarditis, arrhythmia, deep-...

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Veröffentlicht in:	The New England journal of medicine 2021-09, Vol.385 (12), p.1078-1090
Hauptverfasser:	Barda, Noam, Dagan, Noa, Ben-Shlomo, Yatir, Kepten, Eldad, Waxman, Jacob, Ohana, Reut, Hernán, Miguel A, Lipsitch, Marc, Kohane, Isaac, Netzer, Doron, Reis, Ben Y, Balicer, Ran D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Appendicitis Arrhythmia Cardiology Cardiomyopathy Clinical trials Coronavirus Coronaviruses COVID-19 COVID-19 vaccines Electronic health records Embolism Heart diseases Hemorrhage Herpes zoster Infections Infectious Disease Long term health care Lymphadenopathy mRNA mRNA vaccines Myocardial infarction Myocarditis Original Pericarditis Population Safety Severe acute respiratory syndrome coronavirus 2 Surveillance Thrombocytopenia Thrombosis Vaccines
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Beschreibung
Zusammenfassung:	Among more than 1.7 million persons, BNT162b2 vaccination was associated with increased risks of myocarditis (risk ratio, 3.24), lymphadenopathy, appendicitis, and herpes zoster infection; in comparison, Covid-19 increased the risks of myocarditis (risk ratio, 18.28), pericarditis, arrhythmia, deep-vein thrombosis, pulmonary embolism, myocardial infarction, intracranial hemorrhage, and thrombocytopenia.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2110475