Reward Responsiveness in Patients with Opioid Use Disorder on Opioid Agonist Treatment: Role of Comorbid Chronic Pain

Abstract Objective Evidence suggests that blunted reward responsiveness may account for poor clinical outcomes in both opioid use disorder (OUD) and chronic pain. Understanding how individuals with OUD and comorbid chronic pain (OUD+CP) respond to rewards is, therefore, of clinical interest because...

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Veröffentlicht in:Pain medicine (Malden, Mass.) Mass.), 2021-09, Vol.22 (9), p.2019-2027
Hauptverfasser: Finan, Patrick H, Letzen, Janelle, Epstein, David H, Mun, Chung Jung, Stull, Samuel, Kowalczyk, William J, Agage, Daniel, Phillips, Karran A, Pizzagalli, Diego A, Preston, Kenzie L
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Sprache:eng
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Zusammenfassung:Abstract Objective Evidence suggests that blunted reward responsiveness may account for poor clinical outcomes in both opioid use disorder (OUD) and chronic pain. Understanding how individuals with OUD and comorbid chronic pain (OUD+CP) respond to rewards is, therefore, of clinical interest because it may reveal a potential point of behavioral intervention. Methods Patients with OUD (n = 28) and OUD+CP (n = 19) on opioid agonist treatment were compared on: 1) the Probabilistic Reward Task (an objective behavioral measure of reward response bias) and 2) ecological momentary assessment of affective responses to pleasurable events. Results Both the OUD and the OUD+CP groups evidenced an increase in reward response bias in the Probabilistic Reward Task. The rate of change in response bias across blocks was statistically significant in the OUD group (B = 0.06, standard error [SE] = 0.02, t = 3.92, P 
ISSN:1526-2375
1526-4637
DOI:10.1093/pm/pnab031