Specific detection of memory T‐cells in COVID‐19 patients using standardized whole‐blood Interferon gammarelease assay

Antigen‐specific T‐cells are essential for protective immunity against SARS‐CoV‐2. We set up a semi‐automated whole‐blood Interferon‐gamma release assay (WB IGRA) to monitor the T‐cell response after stimulation with SARS‐CoV‐2 peptide pools. We report that the WB IGRA is complementary to serologica...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of immunology 2021-12, Vol.51 (12), p.3239-3242
Hauptverfasser:	Mouton, William, Compagnon, Christelle, Saker, Kahina, Daniel, Soizic, Djebali, Sophia, Lacoux, Xavier, Pozzetto, Bruno, Oriol, Guy, Laubreton, Daphné, Prieux, Margaux, Fassier, Jean‐Baptiste, Guibert, Nicolas, Massardier‐Pilonchéry, Amélie, Alfaiate, Dulce, Berthier, Franck, Walzer, Thierry, Marvel, Jacqueline, Brengel‐Pesce, Karen, Trouiller‐Assant, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Automation, Laboratory Cells, Cultured Cohort Studies COVID-19 COVID-19 - immunology Female Humans immune memory Immunology Interferon interferon gamma release assay Interferon-gamma - metabolism Interferon-gamma Release Tests - standards Letter to the Editor Letters to the Editor Life Sciences Lymphocyte Activation Male Memory T Cells - immunology Middle Aged SARS-CoV-2 - physiology SARS‐CoV‐2 Severe acute respiratory syndrome coronavirus 2 T-Cell Antigen Receptor Specificity T‐cells response Whole Body Imaging Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Antigen‐specific T‐cells are essential for protective immunity against SARS‐CoV‐2. We set up a semi‐automated whole‐blood Interferon‐gamma release assay (WB IGRA) to monitor the T‐cell response after stimulation with SARS‐CoV‐2 peptide pools. We report that the WB IGRA is complementary to serological assays to assess SARS‐CoV‐2 immunity.
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.202149296