SARS-CoV-2-specific T cells in infection and vaccination
During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological r...
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| Veröffentlicht in: | Cellular & molecular immunology 2021-10, Vol.18 (10), p.2307-2312 |
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| creator | Bertoletti, Antonio Le Bert, Nina Qui, Martin Tan, Anthony T. |
| description | During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals. Here, we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals. Understanding whether SARS-CoV-2-specific T cells are more linked to protection or pathogenesis is pivotal to define future therapeutic and prophylactic strategies to manage the current pandemic. |
| doi_str_mv | 10.1038/s41423-021-00743-3 |
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Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals. Here, we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals. 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| subjects | 631/250/2152/1566/1571 692/53/2421 Adaptive immunity Antibodies Biomedical and Life Sciences Biomedicine COVID-19 COVID-19 - immunology COVID-19 - metabolism COVID-19 - prevention & control COVID-19 - virology COVID-19 Vaccines - immunology Humans Immunology Inflammation Lymphocytes Lymphocytes T Medical Microbiology Microbiology Pandemics Review Review Article SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - metabolism T-Lymphocytes - immunology Vaccination Vaccine Viral infections Viruses |
| title | SARS-CoV-2-specific T cells in infection and vaccination |
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