SARS-CoV-2-specific T cells in infection and vaccination
During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological r...
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Veröffentlicht in: | Cellular & molecular immunology 2021-10, Vol.18 (10), p.2307-2312 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals. Here, we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals. Understanding whether SARS-CoV-2-specific T cells are more linked to protection or pathogenesis is pivotal to define future therapeutic and prophylactic strategies to manage the current pandemic. |
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ISSN: | 1672-7681 2042-0226 2042-0226 |
DOI: | 10.1038/s41423-021-00743-3 |