Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions
Background Squamous cell carcinoma is the most common form of malignancy of the oral cavity, and is often proceeded by oral potentially malignant disorders (OPMD). Early detection of oral cavity squamous cell carcinoma (oral cancer) can improve survival rates. The current diagnostic standard of surg...
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Veröffentlicht in: | Cochrane database of systematic reviews 2021-07, Vol.2021 (12), p.CD010276-CD010276 |
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Zusammenfassung: | Background
Squamous cell carcinoma is the most common form of malignancy of the oral cavity, and is often proceeded by oral potentially malignant disorders (OPMD). Early detection of oral cavity squamous cell carcinoma (oral cancer) can improve survival rates. The current diagnostic standard of surgical biopsy with histology is painful for patients and involves a delay in order to process the tissue and render a histological diagnosis; other diagnostic tests are available that are less invasive and some are able to provide immediate results. This is an update of a Cochrane Review first published in 2015.
Objectives
Primary objective: to estimate the diagnostic accuracy of index tests for the detection of oral cancer and OPMD, in people presenting with clinically evident suspicious and innocuous lesions.
Secondary objective: to estimate the relative accuracy of the different index tests.
Search methods
Cochrane Oral Health's Information Specialist searched the following databases: MEDLINE Ovid (1946 to 20 October 2020), and Embase Ovid (1980 to 20 October 2020). The US National Institutes of Health Ongoing Trials Register (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform were also searched for ongoing trials to 20 October 2020. No restrictions were placed on the language or date of publication when searching the electronic databases. We conducted citation searches, and screened reference lists of included studies for additional references.
Selection criteria
We selected studies that reported the diagnostic test accuracy of the following index tests when used as an adjunct to conventional oral examination in detecting OPMD or oral cavity squamous cell carcinoma: vital staining (a dye to stain oral mucosa tissues), oral cytology, light‐based detection and oral spectroscopy, blood or saliva analysis (which test for the presence of biomarkers in blood or saliva).
Data collection and analysis
Two review authors independently screened titles and s for relevance. Eligibility, data extraction and quality assessment were carried out by at least two authors, independently and in duplicate. Studies were assessed for methodological quality using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS‐2). Meta‐analysis was used to combine the results of studies for each index test using the bivariate approach to estimate the expected values of sensitivity and specificity.
Main results
This update included 63 s |
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ISSN: | 1465-1858 1465-1858 1469-493X |
DOI: | 10.1002/14651858.CD010276.pub3 |