A resource of targeted mutant mouse lines for 5,061 genes

The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

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Veröffentlicht in:	Nature genetics 2021-04, Vol.53 (4), p.416-419
Hauptverfasser:	Birling, Marie-Christine, Yoshiki, Atsushi, Adams, David J., Ayabe, Shinya, Beaudet, Arthur L., Bottomley, Joanna, Bradley, Allan, Brown, Steve D. M., Bürger, Antje, Bushell, Wendy, Chiani, Francesco, Chin, Hsian-Jean Genie, Christou, Skevoulla, Codner, Gemma F., DeMayo, Francesco J., Dickinson, Mary E., Doe, Brendan, Donahue, Leah Rae, Fray, Martin D., Gambadoro, Alessia, Gao, Xiang, Gertsenstein, Marina, Gomez-Segura, Alba, Goodwin, Leslie O., Heaney, Jason D., Hérault, Yann, de Angelis, Martin Hrabe, Jiang, Si-Tse, Justice, Monica J., Kasparek, Petr, King, Ruairidh E., Kühn, Ralf, Lee, Ho, Lee, Young Jae, Liu, Zhiwei, Lloyd, K. C. Kent, Lorenzo, Isabel, Mallon, Ann-Marie, McKerlie, Colin, Meehan, Terrence F., Fuentes, Violeta Munoz, Newman, Stuart, Nutter, Lauryl M. J., Oh, Goo Taeg, Pavlovic, Guillaume, Ramirez-Solis, Ramiro, Rosen, Barry, Ryder, Edward J., Santos, Luis A., Schick, Joel, Seavitt, John R., Sedlacek, Radislav, Seisenberger, Claudia, Seong, Je Kyung, Skarnes, William C., Sorg, Tania, Steel, Karen P., Tamura, Masaru, Tocchini-Valentini, Glauco P., Wang, Chi-Kuang Leo, Wardle-Jones, Hannah, Wattenhofer-Donzé, Marie, Wells, Sara, Wiles, Michael V., Willis, Brandon J., Wood, Joshua A., Wurst, Wolfgang, Xu, Ying, Teboul, Lydia, Murray, Stephen A.
Format:	Artikel
Sprache:	eng
Schlagworte:	42/41 631/1647/1511 631/1647/1513/1967 631/208/191/1908 631/532 64/110 692/308/1426 Agriculture Alleles Animal Genetics and Genomics Animals Biomedical and Life Sciences Biomedicine Cancer Research Comment Consortia Developmental genetics Environmental health Functional analysis Gene Deletion Gene Function Gene targeting Genes Genetic aspects Genetic Association Studies Genetic research Genetics Genome Genomes Genotype Genotype & phenotype Human Genetics Information Dissemination International Cooperation Internet Karyotypes Laboratory animals Life Sciences Mammals Mice Mice, Knockout Mouse Embryonic Stem Cells - cytology Mouse Embryonic Stem Cells - metabolism Mutagenesis Mutants Nervous system Neural coding Neurosciences Online databases Phenotype Phenotypes Phenotyping Proteins Quality control Reproducibility Research facilities Rodents Transmissible spongiform encephalopathy Zebrafish
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Beschreibung
Zusammenfassung:	The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/s41588-021-00825-y