Inflammatory pathways amongst people living with HIV in Malawi differ according to socioeconomic status

Background Non-communicable diseases (NCDs) are increased amongst people living with HIV (PLWH) and are driven by persistent immune activation. The role of socioeconomic status (SES) in immune activation amongst PLWH is unknown, especially in low-income sub-Saharan Africa (SSA), where such impacts m...

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Veröffentlicht in:	PloS one 2021-08, Vol.16 (8), p.e0256576-e0256576, Article 0256576
Hauptverfasser:	Kelly, Christine, Tinago, Willard, Alber, Dagmar, Hunter, Patricia, Luckhurst, Natasha, Connolly, Jake, Arrigoni, Francesca, Garcia Abner, Alejandro, Kamn'gona, Raphael, Sheha, Irene, Chammudzi, Mishek, Jambo, Kondwani, Mallewa, Jane, Rapala, Alicja, Mallon, Patrick W. G., Mwandumba, Henry, Klein, Nigel, Khoo, Saye
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiretroviral therapy Biology and Life Sciences Biomarkers - metabolism Carotid-Femoral Pulse Wave Velocity CD4 antigen CD8 antigen Cell activation Childrens health Economic aspects Education Educational Status Family Characteristics Female Growth factors Health aspects Health risks HIV HIV infection HIV Infections - epidemiology HIV Infections - immunology HIV Infections - pathology HIV Infections - physiopathology HIV patients Human immunodeficiency virus Humans Income Inflammation Inflammation - epidemiology Inflammation - immunology Inflammation - pathology Inflammation - physiopathology Low income groups Lymphocytes Lymphocytes T Malawi - epidemiology Male Medicine Medicine and Health Sciences Monocytes Mortality Multidisciplinary Sciences Ownership Pathogens Plasma Proteins Regression analysis Regression models Risk analysis Risk factors Science & Technology Science & Technology - Other Topics Social aspects Social Class Social classes Socioeconomic factors Socioeconomic status Socioeconomics Stiffness Television Tumor necrosis factor-TNF Water Wave velocity
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Beschreibung
Zusammenfassung:	Background Non-communicable diseases (NCDs) are increased amongst people living with HIV (PLWH) and are driven by persistent immune activation. The role of socioeconomic status (SES) in immune activation amongst PLWH is unknown, especially in low-income sub-Saharan Africa (SSA), where such impacts may be particularly severe. Methods We recruited Malawian adults with CD4
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0256576