Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents
In a trial of mRNA-1273 or placebo involving 3700 adolescents 12 to 17 years of age, two doses of vaccine stimulated high levels of neutralizing antibodies, with a side-effect profile similar to that seen in other age groups. The incidence of Covid-19 in the unvaccinated group was too low to gauge p...
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| Veröffentlicht in: | The New England journal of medicine 2021-12, Vol.385 (24), p.2241-2251 |
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| container_title | The New England journal of medicine |
| container_volume | 385 |
| creator | Ali, Kashif Berman, Gary Zhou, Honghong Deng, Weiping Faughnan, Veronica Coronado-Voges, Maria Ding, Baoyu Dooley, Jacqueline Girard, Bethany Hillebrand, William Pajon, Rolando Miller, Jacqueline M Leav, Brett McPhee, Roderick |
| description | In a trial of mRNA-1273 or placebo involving 3700 adolescents 12 to 17 years of age, two doses of vaccine stimulated high levels of neutralizing antibodies, with a side-effect profile similar to that seen in other age groups. The incidence of Covid-19 in the unvaccinated group was too low to gauge protection, but Covid-19 did not develop in any vaccinated participants. |
| doi_str_mv | 10.1056/NEJMoa2109522 |
| format | Article |
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The incidence of Covid-19 in the unvaccinated group was too low to gauge protection, but Covid-19 did not develop in any vaccinated participants.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2109522</identifier><identifier>PMID: 34379915</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>2019-nCoV Vaccine mRNA-1273 - administration & dosage ; 2019-nCoV Vaccine mRNA-1273 - adverse effects ; 2019-nCoV Vaccine mRNA-1273 - immunology ; Adolescence ; Adolescent ; Adolescents ; Adverse events ; Age ; Antibodies, Neutralizing - blood ; Antibodies, Viral - blood ; Child ; Coronavirus ; Coronaviruses ; COVID-19 ; COVID-19 - prevention & control ; Fatigue ; Female ; Headache ; Humans ; Immune response ; Immunization ; Immunogenicity ; Immunogenicity, Vaccine ; Infectious Disease ; Injection ; Male ; mRNA ; Multisystem inflammatory syndrome in children ; Original ; Pain ; Pediatrics ; Placebos ; Safety ; Severe acute respiratory syndrome coronavirus 2 ; Side effects ; Single-Blind Method ; Teenagers ; Vaccine Efficacy ; Vaccines ; Young adults</subject><ispartof>The New England journal of medicine, 2021-12, Vol.385 (24), p.2241-2251</ispartof><rights>Copyright © 2021 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2021 Massachusetts Medical Society.</rights><rights>Copyright © 2021 Massachusetts Medical Society. All rights reserved. 2021 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-54f8b4f2ff4f8894c6b2e8beb058789d13c30456a69446ccd5cef3bba151a1593</citedby><cites>FETCH-LOGICAL-c583t-54f8b4f2ff4f8894c6b2e8beb058789d13c30456a69446ccd5cef3bba151a1593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2109522$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa2109522$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34379915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ali, Kashif</creatorcontrib><creatorcontrib>Berman, Gary</creatorcontrib><creatorcontrib>Zhou, Honghong</creatorcontrib><creatorcontrib>Deng, Weiping</creatorcontrib><creatorcontrib>Faughnan, Veronica</creatorcontrib><creatorcontrib>Coronado-Voges, Maria</creatorcontrib><creatorcontrib>Ding, Baoyu</creatorcontrib><creatorcontrib>Dooley, Jacqueline</creatorcontrib><creatorcontrib>Girard, Bethany</creatorcontrib><creatorcontrib>Hillebrand, William</creatorcontrib><creatorcontrib>Pajon, Rolando</creatorcontrib><creatorcontrib>Miller, Jacqueline M</creatorcontrib><creatorcontrib>Leav, Brett</creatorcontrib><creatorcontrib>McPhee, Roderick</creatorcontrib><title>Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In a trial of mRNA-1273 or placebo involving 3700 adolescents 12 to 17 years of age, two doses of vaccine stimulated high levels of neutralizing antibodies, with a side-effect profile similar to that seen in other age groups. The incidence of Covid-19 in the unvaccinated group was too low to gauge protection, but Covid-19 did not develop in any vaccinated participants.</description><subject>2019-nCoV Vaccine mRNA-1273 - administration & dosage</subject><subject>2019-nCoV Vaccine mRNA-1273 - adverse effects</subject><subject>2019-nCoV Vaccine mRNA-1273 - immunology</subject><subject>Adolescence</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adverse events</subject><subject>Age</subject><subject>Antibodies, Neutralizing - blood</subject><subject>Antibodies, Viral - blood</subject><subject>Child</subject><subject>Coronavirus</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - prevention & control</subject><subject>Fatigue</subject><subject>Female</subject><subject>Headache</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunization</subject><subject>Immunogenicity</subject><subject>Immunogenicity, Vaccine</subject><subject>Infectious Disease</subject><subject>Injection</subject><subject>Male</subject><subject>mRNA</subject><subject>Multisystem inflammatory syndrome in children</subject><subject>Original</subject><subject>Pain</subject><subject>Pediatrics</subject><subject>Placebos</subject><subject>Safety</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Side effects</subject><subject>Single-Blind Method</subject><subject>Teenagers</subject><subject>Vaccine Efficacy</subject><subject>Vaccines</subject><subject>Young adults</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kdtLwzAYxYMobl4efZWCCL5Ec22TF6GMeWNO2HSvIc1S7Wib2awD_3szNocTDIR8kB_nO4cDwBlG1xjx-GbYf3p2mmAkOSF7oIs5pZAxFO-DLkJEQJZI2gFH3s9QOJjJQ9ChjCZSYt4Fsr_UZasXhasjl0fVaJhCTBIajdPRGPbcBJJooo0pahsVdZROXWm9sfXCn4CDXJfenm7eY_B213_tPcDBy_1jLx1AwwVdQM5ykbGc5HkYhGQmzogVmc0QF4mQU0wNRYzHOpaMxcZMubE5zTKNOQ5X0mNwu9adt1llp6vdjS7VvCkq3Xwppwu1-1MXH-rdLZWggnPOgsDVRqBxn631C1UVIUJZ6tq61ivCYyQojzEK6MUfdObapg7xFAlQsJSIFQXXlGmc943Nt2YwUqtS1E4pgT__nWBL_7QQgMs1UFVe1XZW_SP0DbIxkCY</recordid><startdate>20211209</startdate><enddate>20211209</enddate><creator>Ali, Kashif</creator><creator>Berman, Gary</creator><creator>Zhou, Honghong</creator><creator>Deng, Weiping</creator><creator>Faughnan, Veronica</creator><creator>Coronado-Voges, Maria</creator><creator>Ding, Baoyu</creator><creator>Dooley, Jacqueline</creator><creator>Girard, Bethany</creator><creator>Hillebrand, William</creator><creator>Pajon, Rolando</creator><creator>Miller, Jacqueline M</creator><creator>Leav, Brett</creator><creator>McPhee, Roderick</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211209</creationdate><title>Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents</title><author>Ali, Kashif ; Berman, Gary ; Zhou, Honghong ; Deng, Weiping ; Faughnan, Veronica ; Coronado-Voges, Maria ; Ding, Baoyu ; Dooley, Jacqueline ; Girard, Bethany ; Hillebrand, William ; Pajon, Rolando ; Miller, Jacqueline M ; Leav, Brett ; McPhee, Roderick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-54f8b4f2ff4f8894c6b2e8beb058789d13c30456a69446ccd5cef3bba151a1593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>2019-nCoV Vaccine mRNA-1273 - 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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2021-12, Vol.385 (24), p.2241-2251 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | 2019-nCoV Vaccine mRNA-1273 - administration & dosage 2019-nCoV Vaccine mRNA-1273 - adverse effects 2019-nCoV Vaccine mRNA-1273 - immunology Adolescence Adolescent Adolescents Adverse events Age Antibodies, Neutralizing - blood Antibodies, Viral - blood Child Coronavirus Coronaviruses COVID-19 COVID-19 - prevention & control Fatigue Female Headache Humans Immune response Immunization Immunogenicity Immunogenicity, Vaccine Infectious Disease Injection Male mRNA Multisystem inflammatory syndrome in children Original Pain Pediatrics Placebos Safety Severe acute respiratory syndrome coronavirus 2 Side effects Single-Blind Method Teenagers Vaccine Efficacy Vaccines Young adults |
| title | Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents |
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