Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents

In a trial of mRNA-1273 or placebo involving 3700 adolescents 12 to 17 years of age, two doses of vaccine stimulated high levels of neutralizing antibodies, with a side-effect profile similar to that seen in other age groups. The incidence of Covid-19 in the unvaccinated group was too low to gauge p...

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Veröffentlicht in:	The New England journal of medicine 2021-12, Vol.385 (24), p.2241-2251
Hauptverfasser:	Ali, Kashif, Berman, Gary, Zhou, Honghong, Deng, Weiping, Faughnan, Veronica, Coronado-Voges, Maria, Ding, Baoyu, Dooley, Jacqueline, Girard, Bethany, Hillebrand, William, Pajon, Rolando, Miller, Jacqueline M, Leav, Brett, McPhee, Roderick
Format:	Artikel
Sprache:	eng
Schlagworte:	2019-nCoV Vaccine mRNA-1273 - administration & dosage 2019-nCoV Vaccine mRNA-1273 - adverse effects 2019-nCoV Vaccine mRNA-1273 - immunology Adolescent Adolescents Adverse events Age Antibodies, Neutralizing - blood Antibodies, Viral - blood Child Coronavirus Coronaviruses COVID-19 COVID-19 - prevention & control Fatigue Female Headache Humans Immune response Immunization Immunogenicity Immunogenicity, Vaccine Infectious Disease Injection Male mRNA Multisystem inflammatory syndrome in children Original Pain Pediatrics Placebos Safety Severe acute respiratory syndrome coronavirus 2 Side effects Single-Blind Method Teenagers Vaccine Efficacy Vaccines Young adults
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Beschreibung
Zusammenfassung:	In a trial of mRNA-1273 or placebo involving 3700 adolescents 12 to 17 years of age, two doses of vaccine stimulated high levels of neutralizing antibodies, with a side-effect profile similar to that seen in other age groups. The incidence of Covid-19 in the unvaccinated group was too low to gauge protection, but Covid-19 did not develop in any vaccinated participants.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2109522