In Vitro Antibacterial Activity of Cefiderocol against Multidrug-Resistant Acinetobacter baumannii

Cefiderocol (CFDC), a novel siderophore cephalosporin, demonstrates strong activity against multidrug-resistant (MDR) Acinetobacter baumannii. Limited studies have evaluated CFDC alone and in combination with other Gram-negative antibiotics against MDR A. baumannii isolates. Susceptibility testing r...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2021-08, Vol.65 (9), p.e0264620-e0264620
Hauptverfasser:	Abdul-Mutakabbir, Jacinda C, Nguyen, Logan, Maassen, Philip T, Stamper, Kyle C, Kebriaei, Razieh, Kaye, Keith S, Castanheira, Mariana, Rybak, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii Anti-Bacterial Agents - pharmacology Cefiderocol Cephalosporins - pharmacology Drug Resistance, Multiple, Bacterial Mechanisms of Resistance Microbial Sensitivity Tests
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Zusammenfassung:	Cefiderocol (CFDC), a novel siderophore cephalosporin, demonstrates strong activity against multidrug-resistant (MDR) Acinetobacter baumannii. Limited studies have evaluated CFDC alone and in combination with other Gram-negative antibiotics against MDR A. baumannii isolates. Susceptibility testing revealed lower CFDC MIC values (87% of MICs ≤ 4mg/liter) than the comparator Gram-negative agents. Six isolates, with elevated CFDC MICs (16 to 32 mg/liter) were selected for further experiments. Time-kill analyses presented with synergistic activity and beta-lactamase inhibitors increased CFDC susceptibility in each of the isolates.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.02646-20