Comparative effects of artemether and in combination with diminazene aceturate in the treatment of experimental Trypanosoma brucei brucei infection in Wistar rats

This study assessed the effects of artemether and in combination with diminazene aceturate on parasitaemia, weight, haematology and pathology induced by experimentally Trypanosoma brucei brucei infection in Wistar rats. Fifty adult rats comprising 25 each of males and females were assigned into 5 gr...

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Veröffentlicht in:Journal of parasitic diseases 2021-09, Vol.45 (3), p.673-682
Hauptverfasser: Jolayemi, Kelvin Olutimilehin, Mamman, Mohammed, Sani, Dahiru, Okoronkwo, Magdalene Ogbonneya, Udechukwu, Collins Chimezie, Orakpoghenor, Ochuko
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Sprache:eng
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Zusammenfassung:This study assessed the effects of artemether and in combination with diminazene aceturate on parasitaemia, weight, haematology and pathology induced by experimentally Trypanosoma brucei brucei infection in Wistar rats. Fifty adult rats comprising 25 each of males and females were assigned into 5 groups of ten rats (five males and five females). Rats in group I was uninfected while groups II-V were infected with T b brucei . Groups II were untreated; III administered diminazene aceturate once; IV and V administered artemether only and in combination with diminazene aceturate respectively for 5 days. Parasitaemia was determined daily, blood was collected for haematology and weight obtained every four days for a period of 32 days. At 24 days post-treatment, rats were humanely euthanized and organs harvested for pathological examination. Results revealed parasitaemia at day 4 post-infection, significant ( p  
ISSN:0971-7196
0975-0703
DOI:10.1007/s12639-021-01350-9