Zinc-Triggered Hydrogelation of a Self-Assembling β-Hairpin Peptide
Zinc‐chronized gelling: Selective zinc‐triggered hydrogel formation is realized by the self‐assembly of a de novo designed peptide (see picture). A non‐natural, zinc‐binding aminocarboxylate residue is incorporated into the peptide and is used to trigger folding, assembly, and subsequent gelation....
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Veröffentlicht in: | Angewandte Chemie (International ed.) 2011-02, Vol.50 (7), p.1577-1579 |
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creator | Micklitsch, Christopher M Knerr, Patrick J Branco, Monica C Nagarkar, Radhika Pochan, Darrin J Schneider, Joel P |
description | Zinc‐chronized gelling: Selective zinc‐triggered hydrogel formation is realized by the self‐assembly of a de novo designed peptide (see picture). A non‐natural, zinc‐binding aminocarboxylate residue is incorporated into the peptide and is used to trigger folding, assembly, and subsequent gelation. |
doi_str_mv | 10.1002/anie.201006652 |
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A non‐natural, zinc‐binding aminocarboxylate residue is incorporated into the peptide and is used to trigger folding, assembly, and subsequent gelation.</description><subject>Amino Acid Sequence</subject><subject>Circular Dichroism</subject><subject>hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Inverted Repeat Sequences</subject><subject>materials</subject><subject>Molecular Sequence Data</subject><subject>peptides</subject><subject>Peptides - chemistry</subject><subject>Protein Structure, Secondary</subject><subject>self-assembly</subject><subject>zinc</subject><subject>Zinc - chemistry</subject><issn>1433-7851</issn><issn>1521-3773</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EoqVw5Qi5cfLir9jJBWnVr61UFaRuVYmL5TjjYMjGWzsL3b_VH8JvwquUVTlx8kh-5pmZF6G3lMwoIeyjGTzMGMm1lCV7hg5pySjmSvHnuRacY1WV9AC9Sul75quKyJfogFFOqppUh-jkqx8sXkbfdRChLRbbNoYOejP6MBTBFaa4ht7heUqwano_dMXvB7wwPq79UHyB9ehbeI1eONMnePP4HqGbs9Pl8QJffj6_OJ5fYlsSyrASvGqFZQ0IIcu6oVYIUtetcdI5Q2ijmGqEspKXrGmNZE4QThorqBMyA_wIfZq8602zgtbCMEbT63X0KxO3Ohiv__0Z_DfdhZ-64lJKVWfBh0dBDHcbSKNe-WSh780AYZN0jkrkLflu1GwibQwpRXD7KZToXfJ6l7zeJ58b3j3dbY__jToD9QT88j1s_6PT86uL06dyPPX6NML9vtfEH1oqrkp9e3WuyYLfnp0shd7d-X7inQnadNEnfXOddZzQWtCKEP4HSiKo9g</recordid><startdate>20110211</startdate><enddate>20110211</enddate><creator>Micklitsch, Christopher M</creator><creator>Knerr, Patrick J</creator><creator>Branco, Monica C</creator><creator>Nagarkar, Radhika</creator><creator>Pochan, Darrin J</creator><creator>Schneider, Joel P</creator><general>Wiley-VCH Verlag</general><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110211</creationdate><title>Zinc-Triggered Hydrogelation of a Self-Assembling β-Hairpin Peptide</title><author>Micklitsch, Christopher M ; Knerr, Patrick J ; Branco, Monica C ; Nagarkar, Radhika ; Pochan, Darrin J ; Schneider, Joel P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5012-7438d4c2be44659b1c44099daf6ffa01b727b47c6352bda62f4030bc41f46fa03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Amino Acid Sequence</topic><topic>Circular Dichroism</topic><topic>hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Inverted Repeat Sequences</topic><topic>materials</topic><topic>Molecular Sequence Data</topic><topic>peptides</topic><topic>Peptides - chemistry</topic><topic>Protein Structure, Secondary</topic><topic>self-assembly</topic><topic>zinc</topic><topic>Zinc - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Micklitsch, Christopher M</creatorcontrib><creatorcontrib>Knerr, Patrick J</creatorcontrib><creatorcontrib>Branco, Monica C</creatorcontrib><creatorcontrib>Nagarkar, Radhika</creatorcontrib><creatorcontrib>Pochan, Darrin J</creatorcontrib><creatorcontrib>Schneider, Joel P</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Angewandte Chemie (International ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Micklitsch, Christopher M</au><au>Knerr, Patrick J</au><au>Branco, Monica C</au><au>Nagarkar, Radhika</au><au>Pochan, Darrin J</au><au>Schneider, Joel P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zinc-Triggered Hydrogelation of a Self-Assembling β-Hairpin Peptide</atitle><jtitle>Angewandte Chemie (International ed.)</jtitle><addtitle>Angew. 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source | MEDLINE; Access via Wiley Online Library |
subjects | Amino Acid Sequence Circular Dichroism hydrogels Hydrogels - chemistry Inverted Repeat Sequences materials Molecular Sequence Data peptides Peptides - chemistry Protein Structure, Secondary self-assembly zinc Zinc - chemistry |
title | Zinc-Triggered Hydrogelation of a Self-Assembling β-Hairpin Peptide |
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